Edwards syndrome with double trisomy

Tennakoon, J., Kandasamy, Y., Alcock, G., and Koh, T.H.H.G. (2008) Edwards syndrome with double trisomy. Singapore Medical Journal, 49 (7). e190-e191.

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Double trisomy is rare and the only case reported in the literature died soon after birth. We present another case of double trisomy (48XYY, +18) in a male neonate, who was born to a 28-year-old gravida three parity one mother at 35 weeks of gestation. The baby had features of trisomy 18. Karyotype of the patient showed 48, XYY, +18, Ish (DYZ3*2), (D18Z1*3), nuc ish (DYZ3*2), (D18Z1*3). The patient had clinical features of trisomy 18. There was no family history of diabetes mellitus and no exposure to chemicals. It has been suggested that the rarity of Y-chromosome involvement in trisomy 18 may be due to discrepancy between the sexes.

Item ID: 36488
Item Type: Article (Case Study)
ISSN: 0037-5675
Keywords: double trisomy, Edwards syndrome, gonosomal trisomy, karyotype, trisomy 18
Date Deposited: 01 Dec 2014 06:26
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1114 Paediatrics and Reproductive Medicine > 111401 Foetal Development and Medicine @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 100%
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