Abomasal secretion in sheep receiving adult Ostertagia circumcincta that are prevented from contact with the mucosa

Simpson, H.V., Simpson, B.H., Simcock, D.C., Reynolds, G.W., and Pomroy, W.E. (1999) Abomasal secretion in sheep receiving adult Ostertagia circumcincta that are prevented from contact with the mucosa. New Zealand Veterinary Journal, 47 (1). pp. 20-24.

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Abstract

Aims. Both adult and larval Ostertagia circumcincta infections raise abomasal pH and serum gastrin and pepsinogen concentrations, either because of physical effects of the worms or from their chemical secretions. The study was designed to examine whether adult worms require contact with the gastric mucosa to effect changes in gastric secretion.

Methods. Abomasal pH and serum gastrin and pepsinogen concentrations were measured in four groups of sheep: Group A (n = 4): abomasal contents containing about 18 000 adult O. circumcincta were obtained from donor sheep, concentrated and infused into 5 µm mesh porous bags attached to surgically implanted abomasal cannulae. A second worm transplantation was carried out 1 week later to assess worm survival after 16 hours. Group B (n = 4): about 9000 adult worms, recovered after migration out of abomasal contents set in agar, were placed in small 5 µm mesh bags which were inserted through indwelling abomasal cannulae and left for 3 days. Group C (n = 2): about 9000 adult worms from the population recovered from agar were infused through abomasal cannulae which allowed. free movement in the abomasum. Group D (n = 3) was left uninfected.

Results. Worms transplanted directly into the abomasum (Group C) caused rapid and marked effects on abomasal secretion. Adult O. circumcincta died within 16 hours of transfer into the abomasum when they were restrained within porous bags. Nevertheless, in sheep receiving 18 000 worms, abomasal pH increased soon after new feed was presented on Days 1, 2 and 4 after worm transfer; serum gastrin was elevated in three sheep from 113 hours and serum pepsinogen increased in one animal. Sheep receiving 9000 worms showed similar trends but the results were equivocal.

Conclusions. Adult O. circumcincta prevented from physical contact with the gastric mucosa by restraint in porous bags are able to raise abomasal pH. This study implicates parasite excretory-secretory products in mediating changes in gastric secretion caused by adult abomasal worms.

Item ID: 36389
Item Type: Article (Research - C1)
ISSN: 1176-0710
Keywords: sheep, Ostertugia circumcincta , adult worm transfer, abomasal pH, serum gastrin, serum pepsinogen
Funders: C. Alma Baker Trust, E. & C. Thoms Bequest
Date Deposited: 24 Sep 2015 23:05
FoR Codes: 07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070708 Veterinary Parasitology @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences @ 100%
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