A sequential study of the pathology associated with the infection of sheep with adult and larval Ostertagia circumcincta

Scott, I., Khalaf, S., Simcock, D.C., Knight, C.G., Reynolds, G.W., Pomroy, W.E., and Simpson, H.V. (2000) A sequential study of the pathology associated with the infection of sheep with adult and larval Ostertagia circumcincta. Veterinary Parasitology, 89 (1-2). pp. 79-94.

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Abstract

Disturbances in the physiology of the abomasa of sheep infected with either adult Ostertagia circumcincta given via abomasal cannulae, or larvae (L3) given intraruminally were matched by pathological changes in tissues collected by repeated mucosal biopsy. Within 2–3 days of the transplant of adult worms, abomasal pH had increased markedly in five out of six animals, and there also had been rapid increases in serum gastrin and pepsinogen concentrations in all animals. Reductions in parietal cell number were recorded as early as 1 day after the transplant of adults and were associated with the rapid accumulation of many neutrophils and eosinophils. Mucosal hyperplasia, with increased numbers of cells closer in appearance to mucous/mucous neck cells, was a relatively late development, being most pronounced in the latter part of the infection. In sheep given larvae, changes in secretory physiology were again matched by a concurrent fall in parietal cell number and by the accumulation of inflammatory cells. Changes became maximal when most worms could be expected to be present as adults, confirming the role of adults in the natural disease. Some abnormalities were detected in biopsies collected from animals maintained free of parasites and, although milder in degree, there were similarities to those observed in parasitised tissues, there being fewer parietal cells, a modest degree of mucous cell hyperplasia and inflammatory infiltrates of predominantly neutrophils. These changes were the likely result of trauma to the tissues in the immediate vicinity of the cannula, due either to the presence of the cannula itself or to the frequent collection of biopsy material from areas close to it.

Item ID: 36387
Item Type: Article (Research - C1)
ISSN: 1873-2550
Keywords: sheep-Nematoda; Ostertagia circumcincta; abomasum; parietal cells
Funders: Meat New Zealand, C. Alma Baker Trust, E. & C. Thoms Bequest, Massey University
Date Deposited: 24 Sep 2015 23:21
FoR Codes: 07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070708 Veterinary Parasitology @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970107 Expanding Knowledge in the Agricultural and Veterinary Sciences @ 100%
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