A systematic review of circulating markers in primary chronic venous insufficiency

Smith, Ross, and Golledge, Jonathan (2014) A systematic review of circulating markers in primary chronic venous insufficiency. Phlebology, 29 (9). pp. 570-579.

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Abstract

Objectives: The etiology of primary chronic venous insufficiency is poorly understood. This systematic review aimed to summarize published evidence assessing the association of circulating markers with primary chronic venous insufficiency.

Methods: A search was undertaken through the PubMed database using the terms "venous insufficiency" and "biological marker" or "plasma"' or "serum". Search limits included English language, human subjects and studies with publication dates from 1994. Studies which classified patients using the Clinical-Etiology-Anatomy-Pathophysiology system of venous disease were analyzed.

Results: Seventeen studies were included, which have examined > 60 different biomarkers. A total of 13 markers were assessed in > 1 study with the number of primary chronic venous insufficiency cases ranging from 41 to 244 and the number of controls ranging from 30 to 144 in these studies. Circulating estradiol, homocysteine and vascular endothelial growth factor were the most consistently associated with primary chronic venous insufficiency.

Conclusions: Whilst a number of studies have examined biomarkers associated with primary chronic venous insufficiency, further studies are required using improved and standardized approaches on larger populations. Biomarker research may increase pathogenic knowledge and result in opportunities to decrease chronic venous insufficiency burden.

Item ID: 36228
Item Type: Article (Research - C1)
ISSN: 1758-1125
Keywords: venous insufficiency, biological markers, blood, serum, plasma
Funders: Office of Health and Medical Research, Queensland Government, National Health and Medical Research Council of Australia (NHMRC)
Date Deposited: 12 Nov 2014 12:42
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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