The triangular association of ADH1B genetic polymorphism, alcohol consumption and the risk of depression in older men

Almeida, O.P., Hankey, G.J., Yeap, B.B., Golledge, J., and Flicker, L. (2014) The triangular association of ADH1B genetic polymorphism, alcohol consumption and the risk of depression in older men. Molecular Psychiatry, 19 (9). pp. 995-1000.

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Alcohol use, particularly alcohol abuse and dependence, are associated with increased risk of depression. Current diagnostic criteria suggest that the relationship is causal, but the evidence has only been derived from observational studies that are subject to confounding and bias. Given the logistic and ethical constraints that would be associated with a trial of alcohol use to prevent depression, we aimed to complete a Mendelian randomization study to determine if a genetic polymorphism associated with alcohol abuse and dependence (ADH1B rs1229984 G -> A) contributed to modulate the risk of depression in a community-derived cohort of older men. This retrospective analysis of a cohort of 3873 community-dwelling men aged 65-83 years living in the metropolitan region of Perth, Western Australia, investigated the triangular association between the rs1229984 G -> A polymorphism and alcohol use and, after 3.2-8.2 years, the presence of current depression or history of depression. The mean number of standard drinks consumed per week (n; standard deviation; range) according to genotype was AA 1.8 (17; 2.7; 0-7), GA 5.9 (262; 7.5; 0-35), GG 8.5 (3594; 10.9; 0-140) (GG>AA, GG>GA; P<0.001). Consumption of 1 or 2 drinks per day decreased the odds of depression (n = 610) by 30 and 40%, whereas consumption of more than six drinks daily more than doubled the odds of depression (odds ratio: 2.12, 95% confidence interval: 1.02, 4.40). The ADH1B rs1229984 G -> A polymorphism was not associated with current or past depression (P = 0.857). In addition, the presence of the A allele did not interact with the alcohol use to modulate the risk of depression (P = 0.725). These results suggest that alcohol consumption does not cause or prevent depression in older men.

Item ID: 36226
Item Type: Article (Research - C1)
ISSN: 1476-5578
Keywords: alcohol, depression, epidemiology, genetics, Mendelian randomisation, mood disorders
Funders: National Health and Medical Research Council of Australia (NHMRC)
Projects and Grants: NHMRC project grant 279408, NHMRC Project Grant 379600, NHMRC project grant 403963, NHMRC project grant 513823, NHMRC project grant 634492
Date Deposited: 12 Nov 2014 12:42
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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