Reported high salt intake is associated with increased prevalence of abdominal aortic aneurysm and larger aortic diameter in older men

Golledge, Jonathan, Hankey, Graeme J., Yeap, Bu B., Almeida, Osvaldo P., Flicker, Leon, and Norman, Paul E. (2014) Reported high salt intake is associated with increased prevalence of abdominal aortic aneurysm and larger aortic diameter in older men. PLoS ONE, 9 (7). pp. 1-6.

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Abstract

Background: Salt intake has been implicated in the pathogenesis of abdominal aortic aneurysm (AAA) through studies in rodent models but not previously studied in humans. The aim of this study was to examine the association between reported addition of salt to food and the prevalence of AAA.

Methods: A risk factor questionnaire which contained a question about salt intake was included as part of a population screening study for AAA in 11742 older men. AAA presence was assessed by abdominal ultrasound imaging using a reproducible protocol.

Results: The prevalence of AAA was 6.9, 8.5 and 8.6% in men who reported adding salt to food never, sometimes and always, respectively, p = 0.005. Addition of salt to food sometimes (odds ratio [OR]: 1.22, 95% confidence interval [CI]: 1.03-1.44) or always (OR: 1.23, 95% CI 1.04-1.47) was independently associated with AAA after adjustment for other risk factors including age, waist-hip ratio, blood pressure, history of hypertension, high cholesterol, angina, diabetes, myocardial infarction and stroke. Salt intake was also independently associated with aortic diameter (beta 0.023, p = 0.012). In men with no prior history of hypertension, high cholesterol, angina, myocardial infarction or stroke (n = 4185), the association between addition of salt to food sometimes (OR: 1.41, 95% CI 0.96-2.08) or always (OR: 1.52, 95% CI 1.04-2.22) and AAA remained evident.

Conclusion: Reported salt intake is associated with AAA in older men. Additional studies are needed to determine whether reducing salt intake would protect against AAA.

Item ID: 36223
Item Type: Article (Research - C1)
ISSN: 1932-6203
Additional Information:

© 2014 Golledge et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Funders: National Health and Medical Research Council of Australia (NHMRC), Office of Health and Medical Research, Queensland Government
Projects and Grants: NHMRC Grant No. 279408, NHMRC Grant No. 379600, NHMRC Grant No. 403963, NHMRC Grant No. 513823, NHMRC Grant No. 540403, NHMRC Grant No. 540504, NHMRC Grant No. 540405, NHMRC Grant No. 634492, NHMRC Grant No. 1021416, NHMRC Grant No. 1045710, NHMRC Grant No. 1060557
Date Deposited: 12 Nov 2014 12:42
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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