World population stabilization unlikely this century

Gerland, Patrick, Raftery, Adrian E., Ševčiková, Hana, Li, Nan, Gu, Danan, Spoorenberg, Thomas, Alkema, Leontine, Fosdick, Bailey K., Chunn, Jennifer, Lalic, Nevena, Bay, Guiomar, Buettner, Thomas, Heilig, Gerhard K., and Wilmoth, John (2014) World population stabilization unlikely this century. Science, 346 (6206). pp. 234-237.

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Abstract

Neurogenesis is restricted in the adult mammalian brain; most neurons are neither exchanged during normal life nor replaced in pathological situations. We report that stroke elicits a latent neurogenic program in striatal astrocytes in mice. Notch1 signaling is reduced in astrocytes after stroke, and attenuated Notch1 signaling is necessary for neurogenesis by striatal astrocytes. Blocking Notch signaling triggers astrocytes in the striatum and the medial cortex to enter a neurogenic program, even in the absence of stroke, resulting in 850 +/- 210 (mean +/- SEM) new neurons in a mouse striatum. Thus, under Notch signaling regulation, astrocytes in the adult mouse brain parenchyma carry a latent neurogenic program that may potentially be useful for neuronal replacement strategies.

Item ID: 36149
Item Type: Article (Research - C1)
ISSN: 1095-9203
Funders: National Institutes of Health (NIH), Science Foundation Ireland (SFI)
Projects and Grants: NIH grant R01HD54511, NIH grant R01HD070936, SFI ETS Walton visitor award, reference 11/W.1/I2079
Date Deposited: 12 Nov 2014 11:38
FoR Codes: 16 STUDIES IN HUMAN SOCIETY > 1603 Demography > 160305 Population Trends and Policies @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970116 Expanding Knowledge through Studies of Human Society @ 100%
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