Therapeutic efficacy of vitamin E δ-tocotrienol in collagen-induced rat model of arthritis
Haleagrahara, Nagaraja, Swaminathan, Mirashini, Chakravarthi, Srikumar, and Radhakrishnan, Ammu (2014) Therapeutic efficacy of vitamin E δ-tocotrienol in collagen-induced rat model of arthritis. BioMed Research International, 2014. 539540. pp. 1-8.
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Abstract
Rheumatoid arthritis (RA) is a chronic, systemic, inflammatory disease primarily involving inflammation of the joints. Although the management of the disease has advanced significantly in the past three decades, there is still no cure for RA. The aim of this study was to determine the therapeutic efficacy of delta-tocotrienol, in the rat model of collagen-induced arthritis (CIA). Arthritis was induced by intradermal injection of collagen type II emulsified in complete Freund's adjuvant. CIA rats were orally treated with delta-tocotrienol (10 mg/kg) or glucosamine hydrochloride (300 mg/kg) from day 25 to 50. Efficacy was assessed based on the ability to reduce paw edema, histopathological changes, suppression of collagen-specific T-cells, and a reduction in C-reactive protein (CRP) levels. It was established that delta-tocotrienol had the most significant impact in lowering paw edema when compared to glucosamine treatment. Paw edema changes correlated well with histopathological analysis where there was a significant reversal of changes in groups treated with delta-tocotrienol. The results suggest that delta-tocotrienol is efficient in amelioration of collagen-induced arthritis. Vitamin E delta-tocotrienol may be of therapeutic value against rheumatoid arthritis.
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