Hypothyroidism in pregnancy: feto-maternal complications at the Townsville Hospital

Chadwick, Robyn, Srivastava, Divya, Winkle, Matthew, Paul, Daniel, Watson, David, Sangla, Kunwarjit S., and Malabu, Usman (2014) Hypothyroidism in pregnancy: feto-maternal complications at the Townsville Hospital. Annals of the Australasian College of Tropical Medicine, 15 (3). p. 60.

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Abstract

Background/Aims: Untreated hypothyroidism in pregnancy is associated with increased risk of feto-maternal complications including premature birth, low birth weight, gestational hypertension and miscarriage (1,2). However, there is insufficient data on pregnancy outcome in adequately treated hypothyroidism in pregnancy. The aim of the study was to assess feto-maternal complications in hypothyroid pregnant women at the Townsville Hospital.

Method: We collected data by the retrospective chart audit of all the hypothyroid patients who attended the high-risk pregnancy clinic at the Townsville Hospital from 1st January to 31st December 2013. Only patients who were adequately treated with thyroxine and maintained TSH target of < 2.5 mIU/L with regular follow up in the clinic were included in the study.

Results: In all 73 hypothyroid patients were reviewed. 52 were previously diagnosed while 21 were diagnosed to have hypothyroidism during the pregnancy period. Mean age in both groups were similar . Interestingly higher feto-maternal complications were observed in newly diagnosed hypothyroid subjects compared with previously diagnosed hypothyroid patients 25 out of 52- 48%and 14 out of 21- 66.7% respectively X2 = 7.13; p = 0.008. These complications occurred in spite of the adequate thyroxine replacement.

Conclusion: We report higher adverse pregnancy outcome in adequately treated newly diagnosed hypothyroid mothers. Our finding suggests early pre-pregnancy screening for hypothyroidism may lead to reduction in feto-maternal complications in the high risk subjects. Further prospective studies on a larger population are needed to verify our findings.

Item ID: 35830
Item Type: Article (Abstract)
ISSN: 1448-4706
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Date Deposited: 29 Oct 2014 04:38
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110306 Endocrinology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920106 Endocrine Organs and Diseases (excl. Diabetes) @ 100%
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