Evidence based mechanism of Dipeptidyl peptidase IV (DPP4) inihibitors in diabetic foot ulcer healing

Rathnayake, Ayeshmanthe, Saboo, Apoorva, Vangaveti, Venkat N., and Malabu, Usman H. (2014) Evidence based mechanism of Dipeptidyl peptidase IV (DPP4) inihibitors in diabetic foot ulcer healing. Annals of the Australasian College of Tropical Medicine, 15 (3). p. 53.

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Background/Aims: Diabetic foot wounds are one of the most serious complications of the disease giving rise to 84% of all diabetes-related lower limb amputations. Anti-diabetic drug - dipeptidyl peptidase IV (DPP-4) inhibitors have been reported to improve diabetic foot wound healing. However little is known on how it occurs. The objective of the study was to review DPP-4 inhibitors' mechanism of wound healing in subjects with diabetic foot ulcers.

Methods: Published data on DDP-4 inhibitors in wound healing were sought from Medline, PubMed and Google Scholar search of English language literature from 1994 to 2014 using the key words such as "DPP-4 inhibitors", "endothelial healing" "diabetes" and "chronic ulcers".

Results: DPP-4 inhibitors show a potential benefit in processes of wound healing in diabetic chronic foot ulcers. The enzyme inhibitors promote recruitment of endothelial progenitor cells and allow the final scaffolding of wounds. Furthermore DPP-4 inhibitors augment angiogenesis and have widespread effects on optimising the immune response to persistent hypoxia in chronic diabetes wounds.

Conclusion: DPP-4 inhibitors show promise in the local wound healing of diabetic foot ulcers through multiple mechanisms. In the light of high rate of amputations due to non-healing ulcers with profound psychological and economical liability, more investigations on the new role of DPP-4 inhibitors in treatment of diabetic foot ulcer are needed.

Item ID: 35730
Item Type: Article (Abstract)
ISSN: 1448-4706
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Date Deposited: 11 Nov 2014 02:41
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110306 Endocrinology @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920104 Diabetes @ 100%
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