Antioxidant effects of Etlingera elatior flower extract against lead acetate: induced perturbations in free radical scavenging enzymes and lipid peroxidation in rats

Jackie, Tan, Haleagrahara, Nagaraja, and Chakravarthi, Srikumar (2011) Antioxidant effects of Etlingera elatior flower extract against lead acetate: induced perturbations in free radical scavenging enzymes and lipid peroxidation in rats. BMC Research Notes, 4. pp. 1-8.

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Abstract

Background: Etlingera elatior or 'pink torch ginger' (Zingiberaceae) are widely cultivated in tropical countries and used as spices and food flavoring. The purpose of this study was to evaluate the antioxidant effects of Etlingera elatior against lead - induced changes in serum free radical scavenging enzymes and lipid hydroperoxides in rats.

Findings: Rats were exposed to lead acetate in drinking water (500 ppm) for 14 days alone or plus the ethanol extract of E. elatior (50, 100 and 200 mg/kg). Blood lead levels, lipid hydroperoxides, protein carbonyl contents and oxidative marker enzymes were estimated. Lead acetate in drinking water elicited a significant increase in lipid hydroperoxides (LPO) and protein-carbonyl-contents (PCC). There was a significant decrease in total antioxidants, superoxide dismutase, glutathione peroxidase and glutathione S-transferase levels with lead acetate treatment. Supplementation of E. elatior was associated with reduced serum LPO and PCC and a significant increase in total antioxidants and antioxidant enzyme levels.

Conclusions: The results suggest that flower extract of Etlingera elatior has powerful antioxidant effect against lead - induced oxidative stress and the extract may be useful therapeutic agent against lead toxicity. However, detailed evaluations are required to identify the active antioxidant compounds from this plant extract.

Item ID: 35726
Item Type: Article (Research - C1)
ISSN: 1756-0500
Keywords: Etlingera elatior; Rattus; Zingiber officinale; Zingiberaceae
Additional Information:

© Haleagrahara et al; licensee BioMed Central Ltd. 2011 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://​creativecommons.​org/​licenses/​by/​2.​0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Funders: International Medical University, Malaysia
Date Deposited: 28 Oct 2014 00:21
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology @ 45%
11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111506 Toxicology (incl Clinical Toxicology) @ 35%
11 MEDICAL AND HEALTH SCIENCES > 1116 Medical Physiology > 111603 Systems Physiology @ 20%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920405 Environmental Health @ 50%
92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920411 Nutrition @ 50%
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