Neuroprotective effect of bioflavonoid quercetin in 6-hydroxydopamine-induced oxidative stress biomarkers in the rat striatum

Haleagrahara, Nagaraja, Siew, Cheng Jun, Mitra, Nilesh Kumar, and Kumari, Mangala (2011) Neuroprotective effect of bioflavonoid quercetin in 6-hydroxydopamine-induced oxidative stress biomarkers in the rat striatum. Neuroscience Letters, 500 (2). pp. 139-143.

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An increasing large body of research on Parkinson's disease (PD) has focused on the understanding of the mechanisms behind the potential neuro protection offered by antioxidants and iron chelating agents. In this study, the protective effect of the bioflavonoid quercetin on 6-hydroxydopamine (6-OHDA)-induced model of PD was investigated. PD was induced by a single intracisternal injection of 6-hydroxydopamine (300. μg) to male Sprague-Dawley rats. Quercetin treatment (30. mg/kg body weight) over 14 consecutive days markedly increased the striatal dopamine and antioxidant enzyme levels compared with similar measurements in the group treated with 6-OHDA alone. There was a significant decrease in protein carbonyl content in the striatum compared with that of rats that did not receive quercetin. A significant increase in neuronal survivability was also found with quercetin treatment in rats administered 6-OHDA. In conclusion, treatment with quercetin defended against the oxidative stress in the striatum and reduced the dopaminergic neuronal loss in the rat model of PD.

Item ID: 35723
Item Type: Article (Research - C1)
ISSN: 1872-7972
Keywords: biological marker; carbonyl derivative; dopamine; glutathione; lipid hydroperoxide; oxidopamine; quercetin, animal experiment; animal model; animal tissue; article; brain level; cell survival; controlled study; corpus striatum; drug effect; male; neuroprotection; nonhuman; oxidative stress; Parkinson disease; priority journal; rat; treatment duration
Date Deposited: 28 Oct 2014 00:12
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110903 Central Nervous System @ 55%
11 MEDICAL AND HEALTH SCIENCES > 1111 Nutrition and Dietetics > 111103 Nutritional Physiology @ 20%
11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111506 Toxicology (incl Clinical Toxicology) @ 25%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920112 Neurodegenerative Disorders Related to Ageing @ 80%
92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920411 Nutrition @ 20%
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