Cardioprotective effects of glycyrrhizic acid against isoproterenol-induced myocardial ischemia in rats

Haleagrahara, Nagaraja, Varkkey, Julian, and Chakravarthi, Srikumar (2011) Cardioprotective effects of glycyrrhizic acid against isoproterenol-induced myocardial ischemia in rats. International Journal of Molecular Sciences, 12 (10). pp. 7100-7113.

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DOI: 10.3390/ijms12107100

View at Publisher Website: http://dx.doi.org/10.3390/ijms12107100

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Abstract

The aim of the present study was to look into the possible protective effects of glycyrrhizic acid (GA) against isoproterenol-induced acute myocardial infarction in Sprague-Dawley rats. The effect of three doses of glycyrrhizic acid in response to isoproterenol (ISO)-induced changes in 8-isoprostane, lipid hydroperoxides, super oxide dismutase and total glutathione were evaluated. Male Sprague-Dawley rats were divided into control, ISO-control, glycyrrhizic acid alone (in three doses-5, 10 and 20 mg/kg BW) and ISO with glycyrrhizic acid (in three doses) groups. ISO was administered at 85 mg/kg BW at two consecutive days and glycyrrhizic acid was administered intraperitoneally for 14 days. There was a significant increase in 8-isoprostane (IP) and lipid hydroperoxide (LPO) level in ISO-control group. A significant decrease in total superoxide dismutase (SOD) and total glutathione (GSH) was seen with ISO-induced acute myocardial infarction. Treatment with GA significantly increased SOD and GSH levels and decreased myocardial LPO and IP levels. Histopathologically, severe myocardial necrosis and nuclear pyknosis and hypertrophy were seen in ISO-control group, which was significantly reduced with GA treatment. Gycyrrhizic acid treatment proved to be effective against isoproterenol-induced acute myocardial infarction in rats and GA acts as a powerful antioxidant and reduces the myocardial lipid hydroperoxide and 8-isoprostane level.


Item ID:	35721
Item Type:	Article (Research - C1)
ISSN:	1422-0067
Keywords:	oxidative stress; isoproterenol; glycyrrhizic acid; lipid hydroperoxides; 8-isoprostane
Additional Information:	This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Funders:	International Medical University, Kuala Lumpur, Malaysia
Date Deposited:	27 Oct 2014 23:25
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 50% 11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111501 Basic Pharmacology @ 25% 11 MEDICAL AND HEALTH SCIENCES > 1104 Complementary and Alternative Medicine > 110499 Complementary and Alternative Medicine not elsewhere classified @ 25%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 80% 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920411 Nutrition @ 20%
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