Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2

Ahmed, Shana, Thomas, Gilles, Ghoussaini, Maya, Healey, Catherine S., Humphreys, Manjeet K., Platte, Radka, Morrison, Jonathan, Maranian, Melanie, Pooley, Karen A., Luben, Robert, Eccles, Diana, Evans, D. Gareth, Fletcher, Olivia, Johnson, Nichola, dos Santos Silva, Isabel, Peto, Julian, Stratton, Michael R., Rahman, Nazneen, Jacobs, Kevin, Prentice, Ross, Anderson, Garnet L., Rajkovic, Aleksander, Curb, J David, Ziegler, Regina G., Berg, Christine D., Buys, Saundra S., McCarty, Catherine A, Feigelson, Heather Spencer, Calle, Eugenia E., Thun, Michael J., Diver, W. Ryan, Bojesen, Stig, Nordestgaard, Børge G., Flyger, Henrik, Dörk, Thilo, Schürmann, Peter, Hillemanns, Peter, Karstens, Johann H., Bogdanova, Natalia V., Antonenkova, Natalia N., Zalutsky, Iosif V., Bermisheva, Marina, Fedorova, Sardana, Khusnutdinova, Elza, Kang, Daehee, Yoo, Keun-Young, Noh, Dong Young, Ahn, Sei-Hyun, Devilee, Peter, van Asperen, Christi J., Tollenaar, R.A.E.M., Seynaeve, Caroline, Garcia-Closas, Montserrat, Lissowska, Jolanta, Brinton, Louise, Peplonska, Beata, Nevanlinna, Heli, Heikkinen, Tuomas, Aittomäki, Kristiina, Blomqvist, Carl, Hopper, John L., Southey, Melissa C., Smith, Letitia, Spurdle, Amanda B., Schmidt, Marjanka K., Broeks, Annegien, van Hien, Richard R., Cornelissen, Sten, Milne, Roger L., Ribas, Gloria, González-Neira, Anna, Benitez, Javier, Schmutzler, Rita K., Burwinkel, Barbara, Bartram, Claus R., Meindl, Alfons, Brauch, Hiltrud, Justenhoven, Christina, Hamann, Ute, Chang-Claude, Jenny, Hein, Rebecca, Wang-Gohrke, Shan, Lindblom, Annika, Margolin, Sara, Mannermaa, Arto, Kosma, Veli-Matti, Kataja, Vesa, Olson, Janet E., Wang, Xianshu, Fredericksen, Zachary, Giles, Graham G., Severi, Gianluca, Baglietto, Laura, English, Dallas R., Hankinson, Susan E., Cox, David G., Kraft, Peter, Vatten, Lars J., Hveem, Kristian, Kumle, Merethe, Sigurdson, Alice, Doody, Michele, Bhatti, Parveen, Alexander, Bruce H., Hooning, Maartje J., van den Ouweland, Ans M.W., Oldenburg, Rogier A., Schutte, Mieke, Hall, Per, Czene, Kamila, Liu, Jianjun, Li, Yuqing, Cox, Angela, Elliott, Graeme, Brock, Ian, Reed, Malcolm W.R., Shen, Chen-Yang, Yu, Jyh-Cherng, Hsu, Giu-Cheng, Chen, Shou-Tung, Anton-Culver, Hoda, Ziogas, Argyrios, Andrulis, Irene L., Knight, Julia A., Beesley, Jonathan, Goode, Ellen L., Couch, Fergus, Chenevix-Trench, Georgia, Hoover, Robert N., Ponder, Bruce A.J., Hunter, David J., Pharoah, Paul D.P., Dunning, Alison M., Chanock, Stephen J., and Easton, Douglas F. (2009) Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2. Nature Genetics, 41 (5). pp. 585-590.

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Abstract

Genome-wide association studies (GWAS) have identified seven breast cancer susceptibility loci, but these explain only a small fraction of the familial risk of the disease. Five of these loci were identified through a two-stage GWAS involving 390 familial cases and 364 controls in the first stage, and 3,990 cases and 3,916 controls in the second stage1. To identify additional loci, we tested over 800 promising associations from this GWAS in a further two stages involving 37,012 cases and 40,069 controls from 33 studies in the CGEMS collaboration and Breast Cancer Association Consortium. We found strong evidence for additional susceptibility loci on 3p (rs4973768: per-allele OR = 1.11, 95% CI = 1.08–1.13, P = 4.1 times 10-23) and 17q (rs6504950: per-allele OR = 0.95, 95% CI = 0.92–0.97, P = 1.4 times 10-8). Potential causative genes include SLC4A7 and NEK10 on 3p and COX11 on 17q.

Item ID: 35695
Item Type: Article (Research - C1)
ISSN: 1546-1718
Funders:
Date Deposited: 22 Oct 2014 05:53
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111203 Cancer Genetics @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111706 Epidemiology @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%
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