Prevention of surgical site infection in lower limb skin lesion excisions with single dose oral antibiotic prophylaxis: a prospective randomised placebo-controlled double-blind trial
Smith, Samuel C., Heal, Clare F., and Buttner, Petra G. (2014) Prevention of surgical site infection in lower limb skin lesion excisions with single dose oral antibiotic prophylaxis: a prospective randomised placebo-controlled double-blind trial. BMJ Open, 4 (7). e005270. pp. 1-8.
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Abstract
Objectives: To determine the effectiveness of a single perioperative prophylactic 2 g dose of cephalexin in preventing surgical site infection (SSI) following excision of skin lesions from the lower limb.
Design: Prospective double-blinded placebo-controlled trial testing for difference in infection rates.
Setting: Primary care in regional North Queensland, Australia.
Participants: 52 patients undergoing lower limb skin lesion excision.
Interventions: 2 g dose of cephalexin 30–60 min before excision.
Main outcome measures: Incidence of SSI.
Results: Incidence of SSI was 12.5% (95% CI 2.7% to 32.4%) in the cephalexin group compared with 35.7% (95% CI 18.6% to 55.9%) in the placebo group (p=0.064). This represented an absolute reduction of 23.21% (95% CI −0.39% to 46.82%), relative reduction of 65.00% (95% CI −12.70% to 89.13%) and number-needed-to-treat of 4.3.
Conclusions: Administration of a single 2 g dose of cephalexin 30–60 min before skin lesion excision from the lower limb may produce a reduction in the incidence of infection; however, this study was underpowered to statistically determine this.
| Item ID: | 35408 |
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| Item Type: | Article (Research - C1) |
| ISSN: | 2044-6055 |
| Keywords: | randomised controlled trial; surgical site infection; lower limb; skin excision; antibiotic prophylaxis |
| Additional Information: | This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Funders: | James Cook University (JCU), Primary Health Care Research and Information Service |
| Date Deposited: | 24 Sep 2014 00:18 |
| FoR Codes: | 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111716 Preventive Medicine @ 100% |
| SEO Codes: | 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920117 Skin and Related Disorders @ 100% |
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