Predicting coronary heart disease in remote settings: a prospective, cross-sectional observational study

Dwivedi, J., Sutcliffe, S., Easterbrook, L., Woods, C., and Maguire, G.P. (2014) Predicting coronary heart disease in remote settings: a prospective, cross-sectional observational study. Heart, Lung and Circulation, 23 (8). pp. 737-742.

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Background: Coronary heart disease (CHD) places a major burden on the Australian health care system. Determining the likelihood of CHD in a patient presenting with chest pain can be particularly difficult in a remote setting where access to transportation and specialised investigations including myocardial stress studies and coronary angiography can be difficult and delayed. The objective is to develop a predictive model for determining the risk of CHD, including the value of high sensitivity C-reactive protein (hsCRP), in patients presenting with chest pain with a particular emphasis on resources and information likely to be available in a remote primary health care setting.

Methods: A prospective, cross-sectional observational study of patients with no prior diagnosis of CHD presenting to a specialist chest pain assessment clinic at Cairns Hospital from November 2012 to May 2013.

Results: Out of the 163 participants included in the study analyses, a total of 38 were classified as CHD likely (23.3% (95% CI 17.1-30.6)). Logistic regression modelling identified two factors that were independently associated with likely CHD, namely the presence of typical chest pain (OR 83.7 (95% CI 21.7-322.1)) and an abnormal baseline ECG (OR 12.8 (95% CI 1.9-86.0)).

Conclusion: In this study, it was demonstrated that the presence of typical chest pain and an abnormal resting ECG, remain the cornerstone of predicting a subsequent diagnosis of CHD. This information is easily accessible inremote primary health care and should be utilised to expedite assessment in patients presenting withsymptoms suggestive of CHD.

Item ID: 35266
Item Type: Article (Research - C1)
ISSN: 1444-2892
Keywords: C-reactive protein, inflammatory markers, coronary artery disease, diagnosis, chest pain, risk factors
Funders: Far North Queensland Hospital Foundation
Date Deposited: 04 Sep 2014 04:40
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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