Sarnyai, Zoltán, McKittrick, Christina R., McEwen, Bruce S., and Kreek, Mary Jeanne (1998) Selective regulation of dopamine transporter binding in the shell of the nucleus accumbens by adrenalectomy and corticosterone-replacement. Synapse, 30 (3). pp. 334-337.

PDF (Published Version) - Published Version Restricted to Repository staff only

Abstract

[Extract] Chronic stress or high glucocorticoid levels have been shown to affect fundamental brain functions, including emotions, cognition, and reward/reinforcement, and may be associated with psychiatric disorders (McEwen, 1998; Piazza and LeMoal, 1997). Stress and glucocorticoids (GCs) have also been suggested as major factors influencing drug addiction (Kreek, 1996; Piazza and LeMoal, 1997). For example, chronic stress increases the vulnerability to develop psychostimulant selfadministration in a glucocorticoid-responsive manner (for a review, see Piazza and LeMoal, 1997). Moreover, rats have been shown to intravenously self-administer corticosterone (CORT) (see Piazza and LeMoal, 1997), which suggests an important role of CORT in reward related brain processes.

Item ID:	35115
Item Type:	Article (Research - C1)
ISSN:	1098-2396
Keywords:	corticosterone; dopamine transporter; adrenalectomy; nucleus accumbens shell
Funders:	A.V. Davis Fellowship, National Alliance for Research on Schizophrenia and Depression (NARSAD), National Institute of Health (NIH), USA
Projects and Grants:	NARSAD Young Investigator Award, NIH MH41256, NIH DA05130, NIH DA00049
Date Deposited:	28 Aug 2014 06:59
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110903 Central Nervous System @ 100%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 100%
Downloads:	Total: 1
	More Statistics