Properties of a formulated paediatric phenobarbitone oral liquid

Garg, Sanjay, Svirskis, Darren, Myftiu, Joana, Behayaa, Maryam, Shahin, Dina, Thrimawithana, Thilini, Vidicki, Adela, and Kairuz, Therese (2008) Properties of a formulated paediatric phenobarbitone oral liquid. Journal of Pharmacy Practice and Research, 38 (1). pp. 28-31.

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Aim: To formulate a stable and palatable paediatric phenobarbitone 10 mg/mL oral liquid and compare its physicochemical stability to the existing formulation compounded in some New Zealand hospitals.

Method: Formulations were compounded from pharmaceutical standard ingredients according to good manufacturing practices and stored in glass bottles at different storage conditions. The physical stability of the formulations was determined by pH, appearance, viscosity and microbial studies; chemical stability was assessed using high performance liquid chromatography.

Results: The new formulation and the existing hospital formulation remained physically stable for 28 days in terms of pH, appearance, viscosity and microbial stability. The phenobarbitone sodium concentration remained within an acceptable range (above 95% of the original concentration) after 28 days of storage at different conditions. The viscosity of the new formulation facilitated in masking phenobarbitone sodium's bitter taste, thus improving palatability. The palatability of the new formulation was superior to the hospital formulation.

Conclusion: A palatable paediatric phenobarbitone oral liquid formulation with improved rheological properties was developed.

Item ID: 35033
Item Type: Article (Research - C1)
ISSN: 2055-2335
Keywords: formulation; oral liquid; paediatric; stability;
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Date Deposited: 10 Sep 2014 03:43
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1199 Other Medical and Health Sciences > 119999 Medical and Health Sciences not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 100%
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