Chemical stability of extemporaneously compounded omeprazole formulations: a comparison of two methods of compounding

Garg, Sanjay, Svirskis, Darren, Al-Kabban, Majid, Farhan, Samer, Komeshi, Mohammad, Lee, Jacky, Liu, Quincy, Naidoo, Sacha, and Kairuz, Therese (2009) Chemical stability of extemporaneously compounded omeprazole formulations: a comparison of two methods of compounding. International Journal of Pharmaceutical Compounding, 13 (3). pp. 250-253.

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Liquid preparations of omeprazole are compounded extemporaneously for patients who cannot tolerate or have difficulty with tablets or capsules, such as those with a nasogastric tube or jejunal or feeding tube, those with a swallowing disorder, and young children and the elderly. Recommendations for preparation of a liquid from the enteric-coated pellets of omeprazole capsules are available in the literature. The pellets are dissolved in a sodium bicarbonate solution; shaking is recommended to aid dissolution. Apparently some pharmacists crush the pellets to speed up the compounding process. The aim of this study was to investigate the chemical stability of omeprazole in extemporaneously compounded liquids prepared by the grinding and shaking methods. A high-performance liquid chromatographic method was developed for evaluation of chemical stability. Samples were stored at 2°C (refrigerated conditions) or 25°C/60% relative humidity and assayed for drug concentration at 0, 1, 2, 4, and 8 weeks. The method of preparation affected the chemical stability of omeprazole when stored at 25°C/60% relative humidity; it was stable for 4 weeks if prepared by the shaking method, but for only 1 week if prepared by the grinding method. For both methods, the suspension was stable for 8 weeks if stored under refrigerated conditions. It is recommended that the shaking method be employed for extemporaneously compounded omeprazole suspensions, and that the prepared suspension be stored in the refrigerator.

Item ID: 35028
Item Type: Article (Research - C1)
ISSN: 1943-5223
Keywords: compounding; stability; omeprazole; suspensions
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Date Deposited: 18 Sep 2014 04:06
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1199 Other Medical and Health Sciences > 119999 Medical and Health Sciences not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9299 Other Health > 929999 Health not elsewhere classified @ 100%
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