Control of salt and volume retention cannot be ruled out as a mechanism underlying the blood pressure-lowering effect of renal denervation

Wang, Yutang, Denton, Kate M., and Golledge, Jonathan (2013) Control of salt and volume retention cannot be ruled out as a mechanism underlying the blood pressure-lowering effect of renal denervation. Hypertension Research, 36. 1006-1007 .

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View at Publisher Website: http://dx.doi.org/10.1038/hr.2013.82
 
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Abstract

[Extract] Catheter-based renal denervation (RDN) has been increasingly used to lower blood pressure (BP) in patients with treatment-resistan hypertension. However, the underlying mechanisms by which RDN is effective are not well understood.

In Hypertension Research, Kimura published commentary titled 'Future of catheter-based renal denervation: key issues to solve', which identified some key issues for future research in RDN. The author correctly pointed out that there exist salt - and volume - independent mechanisms underlying the BP-lowing effect of RDN, for example, a decrease in renal vascular resistence, a decrease in renin-angiotensin system activity and a decrease in afferent nerve activity. However, Kimura suggested that control of salt and volume retention is not the mechanism by which RDN lowers BP, based on what we consider two inappropriate pieces of evidence.

Item ID: 34894
Item Type: Article (Commentary)
ISSN: 1348-4214
Date Deposited: 30 Sep 2014 04:09
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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