Wang, Yutang, Denton, Kate M., and Golledge, Jonathan (2013) Control of salt and volume retention cannot be ruled out as a mechanism underlying the blood pressure-lowering effect of renal denervation. Hypertension Research, 36. 1006-1007 .

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Abstract

[Extract] Catheter-based renal denervation (RDN) has been increasingly used to lower blood pressure (BP) in patients with treatment-resistan hypertension. However, the underlying mechanisms by which RDN is effective are not well understood.

In Hypertension Research, Kimura published commentary titled 'Future of catheter-based renal denervation: key issues to solve', which identified some key issues for future research in RDN. The author correctly pointed out that there exist salt - and volume - independent mechanisms underlying the BP-lowing effect of RDN, for example, a decrease in renal vascular resistence, a decrease in renin-angiotensin system activity and a decrease in afferent nerve activity. However, Kimura suggested that control of salt and volume retention is not the mechanism by which RDN lowers BP, based on what we consider two inappropriate pieces of evidence.

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