Atypical antipsychotic-induced diabetes mellitus: an update on epidemiology and postulated mechanisms

Buchholz, S., Morrow, A.F., and Coleman, P.L. (2008) Atypical antipsychotic-induced diabetes mellitus: an update on epidemiology and postulated mechanisms. Internal Medicine Journal, 38 (7). pp. 602-606.

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Diabetic ketoacidosis and hyperglycaemic hyperosmolar syndrome are rare, but potentially fatal complications of antipsychotic-associated hyperglycaemia. The mechanisms for this remain unclear, but are probably multifactorial. The suggested reasons include drug-induced weight gain and adiposity, development of the metabolic syndrome, antagonism of serotonin (5-hydroxytryptamine) receptors, drug-induced leptin resistance, dyslipidaemia mediated pancreatic β-cell damage and hepatocyte transcription factor dysregulation. Patients with schizophrenia are known to be at a higher genetic risk of developing diabetes mellitus and cardiovascular disease. This review emphasizes a rare case of hyperosmolar hyperglycaemic syndrome in a young man with schizophrenia and discusses proposed mechanisms for the development of antipsychotic-associated diabetes mellitus.

Item ID: 34790
Item Type: Article (Research - C1)
ISSN: 1445-5994
Keywords: atypical antipsychotic; diabetes mellitus; diabetic ketoacidosis; hyperosmolar hyperglycaemic syndrome
Date Deposited: 16 Sep 2014 05:42
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111714 Mental Health @ 40%
11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110306 Endocrinology @ 60%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920104 Diabetes @ 80%
92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920410 Mental Health @ 20%
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