Targets for medical therapy to limit abdominal aortic aneurysm progression

Emeto, Theophilus I., Seto, Sai-Wang, and Golledge, Jonathan (2014) Targets for medical therapy to limit abdominal aortic aneurysm progression. Current Drug Targets, 15 (9). pp. 860-873.

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Abstract

Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. Most AAAs are asymptomatic and screening programs have been introduced to identify AAAs at an early stage in some countries. There is currently no accepted therapy for early stage or small AAAs, which are frequently identified by such programs. In this review, we discuss work underway to identify targets for medical treatments to limit progression of small AAAs. Specifically we discuss studies, which have examined the potential of targeting inflammation, proteolysis, the renin-angiotensin system, the coagulation system and sex hormones as approaches to limiting AAA pathogenesis. As yet, none of the treatment targets have translated into an agent, which can effectively reduce AAA progression in clinical practice.

Item ID: 34322
Item Type: Article (Research - C1)
ISSN: 1873-5592
Keywords: abdominal aortic aneurysm, pharmacotherapy, clinical trial, animal models
Funders: National Health and Medical Research Council (NHMRC), Queensland Government, Townsville Hospital Private Practice Trust Fund, National Heart Foundation of Australia (NHF)
Projects and Grants: NHMRC project grant number 1063476, NHMRC project grant number 1022752, NHMRC project grant number 1021416, NHMRC project grant number 1020955, NHMRC project grant number 1003707, NHMRC Practioner Fellowship number 1019921, NHMRC Centre of Excellence number 1000967, NHF Fellowship PF12B6825
Date Deposited: 16 Sep 2014 00:28
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111502 Clinical Pharmacology and Therapeutics @ 30%
11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111706 Epidemiology @ 20%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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