Morphological analysis of supernumerary teeth in CEBP/beta knock-out mice

Tsukamoto, Hiroko, Takahashi, Katsu, Togo, Yumiko, Kiso, Honoka, Saito, Kazuyuki, Huang, Boyen, and Bessho, Kazuhisa (2012) Morphological analysis of supernumerary teeth in CEBP/beta knock-out mice. In: Abstracts from the 57th Congress of the Japanese Society of Oral and Maxillofacial Surgeons. From: 57th Congress of the Japanese Society of Oral and Maxillofacial Surgeons, 19-21 October 2012, Yokohama, Japan.

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Abstract

Aims: Recently, relationships between CEBP/beta and hard tissue formation such as osteogenesis, chondrogenesis, and odontogenesis have been reported. Regarding osteogenesis, CEBP/beta regulates IGF1, Runx2, osteocalcin and Cdknlc. As for odontogenesis, CEBP/beta is associated with DSPP which influences differentiation of dentinoblasts. Here we report supernumerary teeth in mice with CEBP/beta deficiency, with an approach of morphological analysis.

Materials and Methods: The maxilla and mandible of 12-week-old CEBP/beta deficient mice were examined with micro-CT and HE stain methods.

Results: Under micro-CT, supernumerary teeth were identified in CEBP/beta deficient mice. The supernumerary teeth were located near the radicular area of upper incisors. Under microscopy, the supernumerary teeth located near upper incisors were also confirmed. The supernumerary teeth showed an evidence of dentine and pulp tissue. This implied to formation of normal dental tissues.

Conclusions: Formation of supernumerary teeth was related to CEBP/beta mutation. Because the cause of formation of supernumerary teeth remained unclear, future investigation in mechanisms of CEBP/beta on tooth formation is indicated. In addition, succeeding studies into supernumerary teeth of humans are required.

Item ID: 34287
Item Type: Conference Item (Abstract / Summary)
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Date Deposited: 12 Aug 2014 03:13
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1105 Dentistry > 110504 Oral and Maxillofacial Surgery @ 40%
11 MEDICAL AND HEALTH SCIENCES > 1105 Dentistry > 110507 Paedodontics @ 60%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920113 Oro-Dental Disorders @ 100%
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