Blood-feeding human hookworm proteases

Loukas, A., Ranjit, N., Pickering, D.A., and Pearson, M.S. (2012) Blood-feeding human hookworm proteases. In: Dunn, Ben, (ed.) Proteinases as Drug Targets. Royal Society of Chemistry, Cambridge, UK, pp. 186-198.

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Proteases are pivotal to parasitism, mediating biological processes crucial to the survival of parasitic helminth (worms). Hookworms live in the small intestine of their mammalian hosts, and bury their anterior ends under the mucosa where they rupture the capillaries and feed on the extravasated blood. A suite of proteases are expressed in the intestine of the hookworm, where they act to degrade host hemoglobin and serum proteins as part of the feeding process. These proteases are exposed to components of the host's immune system when the worms ingest blood, and therefore present as targets for the development of anti-helminth vaccines and prophylactic drugs. The protective effects of current vaccine antigens against hookworms and related nematodes of livestock (barber's pole worm) are based on hemoglobin-degrading intestinal proteases and act largely due to the neutralization of these proteases by antibodies that are ingested with the blood meal. In this chapter, we survey the current status of hookworm and proteases that show promise as vaccines and describe their vital contribution to a parasitic existence.

Item ID: 34157
Item Type: Book Chapter (Research - B1)
ISBN: 978-1-84973-049-5
Date Deposited: 01 Dec 2014 02:20
FoR Codes: 06 BIOLOGICAL SCIENCES > 0605 Microbiology > 060599 Microbiology not elsewhere classified @ 50%
06 BIOLOGICAL SCIENCES > 0601 Biochemistry and Cell Biology > 060107 Enzymes @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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