Human papilloma virus infection in Indian nasopharyngeal carcinomas in relation to the histology of tumour

Krishna, S.M., James, S., Kattoor, J., and Balaram, P. (2004) Human papilloma virus infection in Indian nasopharyngeal carcinomas in relation to the histology of tumour. Indian Journal of Patholology and Microbiology, 47 (2). pp. 181-185.

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Abstract

Nasopharyngeal carcinoma (NPC) is a rare malignancy world-wide. It shows an increasing trend in the southern parts of India. Genetic alterations brought about by environmental factors, HPV and EBV are thought to be crucial for NPC carcinogenesis. This study reports for the first time the incidence of HPV infection in NPC in Southern India. Detection of HPV was carried out in 36 NPC and 10 adenoid lesions by immunohistochemical analysis. 38.8% of NPC were positive for HPV with higher positivity in WHO Type I and WHO Type II cancers. One among 10 adenoid lesions also showed presence of HPV. The patients belonged to low socio-economic status and had exposure to either tobacco or alcohol alone or in combination or kitchen smoke.

Item ID: 33997
Item Type: Article (Refereed Research - C1)
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ISSN: 0974-5130
Date Deposited: 05 Aug 2015 00:37
FoR Codes: 06 BIOLOGICAL SCIENCES > 0605 Microbiology > 060502 Infectious Agents @ 15%
06 BIOLOGICAL SCIENCES > 0605 Microbiology > 060506 Virology @ 15%
11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111201 Cancer Cell Biology @ 70%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%
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