Crowther, Caroline A., Doyle, Lex W., Haslam, Ross R., Hiller, Janet E., Harding, Jane E., Robinson, Jeffrey S., Ashwood, P., Paynter, J., Holst, C., Robinson, K., Willson, K., Lumley, J., Carlin, J., Carse, E., Ratnapala, M., Hanafy, A., Reid, R., Austin, N., Darlow, B., Hunter, J., Liley, H., Mogridge, N., Poad, D., Broadbent, R., Gillies, K., Patel, F., Tout, S., Wilson, D., Ludwig, D., Carman, G., Ende, K., Heininger, J., Tan, F., Van der Westhuyzen, J., Giles, W., Gill, A., Miljkovic, L., Nicoll, A., O’Callaghan, S., Vimpani, A., Chan, F., Flenady, V., Cincotta, R., Gray, P., Hegarty, J., Jenkins-Manning, S., Lewis, L., Liley, H., Poulsen, L., Rogers, Y., Toohill, J., Tudehope, D., Woodgate, P., Mildenhall, L., Brown, I., Hayward, L., Smith, D.W., Thesing, A., Wadsworth, S., Burrows, R., Charlton, M., Hayes, M., Taylor, N., Yu, V., McCowan, L., Taylor, R., Bevan, C., Aftimos, S., Alsweiler, J., Armstrong, D., Battin, M., Dezoete, J.A., Light, M., Stone, P., Thesing, A., Webster, N., West, C., Kuschel, C., Gillies, K., Bates, G., Baillie, D., Hastings, L., Jory, A., Mercer, P., Pullen, R., Scott, G., Bury, G., Bacic, S., Butterley, K., Giannaros, H., Jarrell, S., Standen, G., Fisher, C., Challis, D., Asgill, K., Buist, R., Cameron, D., Dyer, K., Lui, K., Milner, S., Sutton, L., Woodhart, L., Morris, J., Bowen, J., Gallimore, V., Gibson, F., Leslie, G., Maher, C., Child, A., Henderson-Smart, D., Jeffery, H., Ogle, R., Osborn, D., Peat, B., Phipps, H., Polverino, J., Rieger, I., Vaughan, J., Wocadlo, C., Colditz, P., Allen, R., de Dassel, T., Fitzsimmons, T., Horn, J., Katterns, W., Pritchard, M., Smith-Orr, V., Somville, T., Wilson, J., Wilson, M., Reynolds, G., Downes, P., Ellwood, D., Hand, P., Jacob, E., Lindgren, J., Nugent, J., Peek, M., Ringland, C., Rollason, C., Watkins, A., Fraser, S., Wein, P., Higgins, J., Kelly, E., Keng, J., McCarthy, E., Turner, A., Walker, S., Woods, H., Brennecke, S., Callanan, C., Davis, N., Ford, G., Howard, K., Kelly, E., Kornman, L., Lim, M., McGrath, G., Rushford, D., Watson, D., Blair, A., Campbell, S., Dederer, A., Green, E., Lawrence, A., Roberts, G., Roberts, K., Whitehall, J., Ratnapala, M., Chadha, Y., Gibson, E.D., Morris, B., Bourchier, D., Haslam, A., Holmes, C., McLaughlin, R., Meher-Homji, N., Reetz, J., Weston, P., Sangalli, M., Bedford, N., Calvert, S., Coles, C., Corbett, G., Elder, D., Preston, U., Richardson, V., Barnett, C., Bhatia, V., Coppinger, V., Deussen, A., Dodd, J., Fitzgerald, J., Gibbons, S., Griffith, E., Harris, K., Headley, B., Holst, C., Khong, T.Y., Lioulios, E., McLaughlin, K., McPhee, A., O’Grady, M., Paine, B., Paynter, J., Ramsay, J., Robinson, K., Russell, S., Santich, M., Vigneswaren, R., and Zhang, L. (2007) Outcomes at 2 Years of Age after Repeat Doses of Antenatal Corticosteroids. New England Journal of Medicine, 357 (12). pp. 1179-1189.

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Abstract

Background: We previously reported the results of a randomized, controlled trial showing that repeat doses of antenatal corticosteroids reduced the risk of respiratory distress syndrome and serious neonatal morbidity. However, data have not been available regarding longer-term effects of this treatment.

Methods: Women who had received an initial course of corticosteroid treatment 7 or more days previously were randomly assigned to receive an intramuscular injection of corticosteroid (11.4 mg of betamethasone) or saline placebo; the dose was repeated weekly if the mother was still considered to be at risk for preterm delivery and the duration of gestation was less than 32 weeks. We assessed survival free of major neurosensory disability and body size of the children at 2 years of corrected age.

Results: Of the 1085 children who were alive at 2 years of age, 1047 (96.5%) were seen for assessment (521 exposed to repeat-corticosteroid treatment and 526 exposed to placebo). The rate of survival free of major disability was similar in the repeatcorticosteroid and placebo groups (84.4% and 81.0%, respectively; adjusted relative risk, 1.04, 95% confidence interval, 0.98 to 1.10; adjusted P = 0.20). There were no significant differences between the groups in body size, blood pressure, use of health services, respiratory morbidity, or child behavior scores, although children exposed to repeat doses of corticosteroids were more likely than those exposed to placebo to warrant assessment for attention problems (P = 0.04).

Conclusion: Administration of repeat doses of antenatal corticosteroids reduces neonatal morbidity without changing either survival free of major neurosensory disability or body size at 2 years of age.

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