Ariyawardana, A., Athukorala, A.D.S., and Arulanandam, A. (2006) Effect of betel chewing, tobacco smoking and alcohol consumption on oral submucous fibrosis: a case-control study in Sri Lanka. Journal of Oral Pathology & Medicine, 35 (4). pp. 197-201.

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Abstract

Background:  Oral submucous fibrosis (OSMF) is a chronic, insidious, disabling potentially malignant condition of the oral mucosa seen predominantly in south and Southeast Asia. No reports are hitherto available on the aetiological factors of OSMF based on Sri Lankan patients.

Methods:  A total of 74 patients with OSMF and 74 controls who consecutively attended the Oral Medicine clinic at the Dental Hospital (Teaching) Faculty of Dental Sciences, University of Peradeniya, Sri Lanka were included in the study. Binary logistic regression analyses were performed to model the influence of betel chewing, smoking and alcohol use and to determine the effects of different combinations of chewing habits on OSMF.

Results:  Betel chewing was the only significantly associated factor in the aetiology of OSMF (OR = 171.83, 95% CI: 36.35–812.25). There were no interaction effects of chewing, smoking and alcohol consumption in the causation of OSMF.

Conclusion:  The present study has shown a strong association of betel quid chewing (including tobacco as an ingredient) with the causation of OSMF.

Item ID:	33680
Item Type:	Article (Research - C1)
ISSN:	1600-0714
Keywords:	alcohol; areca nut; betel chewing; case–control; pre-cancer; submucous fibrosis; tobacco
Date Deposited:	16 Oct 2015 01:25
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1105 Dentistry > 110505 Oral Medicine and Pathology @ 100%
SEO Codes:	92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920113 Oro-Dental Disorders @ 100%
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