Influence of titanium dioxide particle size on the photostability of the chemical UV-Filters butyl methoxy dibenzoylmethane and ctocrylene in a microemulsion

Kockler, Jutta, Oelgemöller, Michael, Robertson, Sherryl, and Glass, Beverley D. (2014) Influence of titanium dioxide particle size on the photostability of the chemical UV-Filters butyl methoxy dibenzoylmethane and ctocrylene in a microemulsion. Cosmetics, 1 (2). pp. 128-139.

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Abstract

Sunscreen products often contain combinations of ultraviolet (UV)-filters in order to achieve broad spectrum protection from exposure to sunlight. The inclusion of both chemical and physical UV-filters in these products, however, increases the possibility for both photolytic and photocatalytic reactions to occur. This study investigated the effect of titanium dioxide (TiO2) particle size on the photostability of the chemical UV-filters butyl methoxy dibenzoylmethane (BMDM) and octocrylene (OC) formulated in a microemulsion. The International Conference on Harmonisation (ICH) Guideline Q1B for photostability testing of new active substances and medicinal products was applied. BMDM and OC in the microemulsion were irradiated with simulated sunlight in the presence of nano- (<25 nm) and micro-TiO2 (~0.6 μm) and their concentrations determined using a validated high performance liquid chromatography (HPLC) method. For the combination of BMDM and OC, the photodegradation for BMDM was found to be 12% higher in the presence of nano-TiO2 as compared to that of the micro-TiO2. This enhanced photodegradation is attributed to the larger surface area of the nano-TiO2 and the increased generation of reactive oxygen species (ROS). Because of these findings, sunscreen products containing chemical UV-filters and nano-TiO2 should be regarded with caution, due to the potential loss of photoprotection.

Item ID: 33643
Item Type: Article (Research - C1)
ISSN: 2079-9284
Keywords: photostability; titanium dioxide; particle size; nano-TiO2; microemulsion; butyl methoxy dibenzoylmethane; octocrylene; high performance liquid chromatography (HPLC)
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© 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

Funders: James Cook University
Date Deposited: 12 Jun 2014 04:59
FoR Codes: 03 CHEMICAL SCIENCES > 0305 Organic Chemistry > 030505 Physical Organic Chemistry @ 30%
11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111504 Pharmaceutical Sciences @ 70%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 30%
97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 70%
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