Role of toll-like receptors in multiple sclerosis

Miranda-Hernandez, Socorro, and Baxter, Alan (2013) Role of toll-like receptors in multiple sclerosis. American Journal of Clinical and Experimental Immunology, 2 (1). pp. 75-93.

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Abstract

Multiple Sclerosis (MS) is an autoimmune disease in which Central Nervous System (CNS) lesions result from perivascular immune cell infiltration associated with damage to myelin, oligodendrocytes and neurons. CNS autoimmunity and its regulation are dominated by the inflammatory cytokines IL17 and IFNγ, and the opposing regulatory cytokines IL10 and the type I IFNs. Toll-like receptors (TLR) play a critical role in modulating cytokine and chemokine secretion in response to exogenous Pathogen Associated to Molecular Patterns and endogenous Danger-Associated to Molecular Patterns. Here, we systematically examine the evidence that TLR play a major role in the initiation disease, the triggering of relapses, and regulation of CNS damage. Data from human studies are supported analyses of a variety of animal models, including Experimental Autoimmune Encephalomyelitis in TLR-deficient mice.

Item ID: 33475
Item Type: Article (Refereed Research - C1)
Keywords: multiple sclerosis, toll-like receptors, hygiene hypothesis, microbial flora, gene/environment interactions, autoimmunity, TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8, TLR9, TLR10
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AJCEI Copyright Policy: Once the paper is published, the copyright will be released by the publisher under the "Creative Commons Attribution Noncommercial License", enabling the unrestricted non-commercial use, distribution, and reproduction of the published article in any medium, provided that the original work is properly cited.

ISSN: 2164-7712
Funders: National Health and Medical Research Council of Australia (NHMRC), Australian Research Council (ARC), Lions Clubs of Australia, Multiple Sclerosis Research Australia
Date Deposited: 03 Jun 2014 23:53
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110703 Autoimmunity @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920108 Immune System and Allergy @ 90%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 10%
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