Leontiasis ossea: a presentation of hyperparathyroidism in an Indigenous Australian man secondary to chronic renal failure

Collum, Justin, Jones, Robert H.B., Lynham, Anthony, and Hirst, Julian (2013) Leontiasis ossea: a presentation of hyperparathyroidism in an Indigenous Australian man secondary to chronic renal failure. Journal of Oral and Maxillofacial Surgery, 71 (1). pp. 56-61.

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Abstract

[Extract] Leontiasis ossea is a term that can be used to describe the progressive hypertrophy of facial and cranial bones associated with a group of diseases, including Paget disease and fibrous dysplasia, 1 and in patients with chronic renal failure and secondary hyperparathyroidism. It is important that the clinician is aware of the diagnosis and management of this debilitating condition. Although rare, the consequences of poor management and treatment can be serious. Furthermore, patients who are diagnosed with this condition require intensive management by a multidisciplinary team.

Chronic renal failure is the progressive and irreversible loss of renal function that can result in end-stage renal disease requiring dialysis or transplantation for survival. 2 Chronic renal failure results in hyperphosphatemia and hypocalcemia, which increases the production of the parathyroid hormone (PTH), with subsequent hypercalcemia. This results in increased bone formation and resorption. 2 The effects of this process result in a range of musculoskeletal manifestations referred to as renal osteodystrophy. At the extreme of this range is a complication of chronic renal failure known as uremic leontiasis ossea. 1 and 3

Item ID: 33368
Item Type: Article (Research - C1)
ISSN: 1531-5053
Date Deposited: 25 May 2014 06:37
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1105 Dentistry > 110504 Oral and Maxillofacial Surgery @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110399 Clinical Sciences not elsewhere classified @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920113 Oro-Dental Disorders @ 50%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920116 Skeletal System and Disorders (incl. Arthritis) @ 50%
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