Combination of N-Acetyl-L-Tryptophan and Magnesium Sulphate for the treatment of brain, spinal and nerve injury

Vink, Robert, and Nimmo, Alan F. Hoffmann-La Roche AG (2009) Combination of N-Acetyl-L-Tryptophan and Magnesium Sulphate for the treatment of brain, spinal and nerve injury. EP 1 261 335 B1 .

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Abstract

This invention relates to a method of therapy of brain, spinal and nerve injury. There is also provided a formulation which is particularly useful in the method. Injury to the brain results in the development of motor and cognitive deficits that contribute to the significant morbidity experienced by survivors of brain injury. Moreover, it is an occurrence that has the highest incidence in younger members of society. Accordingly, injury to the brain is responsible for the greatest loss of productive life as compared to any other disease process. Despite this, there is no effective therapy to improve outcome after brain injury. Use of this therapy significantly improves both motor and cognitive outcome in mild to severe experimental brain injury and has also been found to have beneficial effect also for the treatment of spinal cord and nerve injuries.

Item ID: 33299
Item Type: Patent
Keywords: brain injury; substance P; cerebral oedema; magnesium; n-acetyl tryptophan; NK1 receptor antagonist
Funders: James Cook University Merit Research Grant
Date Deposited: 04 Aug 2017 04:46
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1109 Neurosciences > 110903 Central Nervous System @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1115 Pharmacology and Pharmaceutical Sciences > 111502 Clinical Pharmacology and Therapeutics @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920111 Nervous System and Disorders @ 100%
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