Brannelly, Laura (2014) Reduced itraconazole concentration and durations are successful in treating Batrachochytrium dendrobatidis infection in amphibians. Journal of Visualized Experiments, 85. e51166. pp. 1-6.

PDF (Published Version) - Published Version Restricted to Repository staff only

Abstract

Amphibians are experiencing the greatest decline of any vertebrate class and a leading cause of these declines is a fungal pathogen, Batrachochytrium dendrobatidis (Bd), which causes the disease chytridiomycosis. Captive assurance colonies are important worldwide for threatened amphibian species and may be the only lifeline for those in critical threat of extinction. Maintaining disease free colonies is a priority of captive managers, yet safe and effective treatments for all species and across life stages have not been identified. The most widely used chemotherapeutic treatment is itraconazole, although the dosage commonly used can be harmful to some individuals and species. We performed a clinical treatment trial to assess whether a lower and safer but effective dose of itraconazole could be found to cure Bd infections. We found that by reducing the treatment concentration from 0.01-0.0025% and reducing the treatment duration from 11-6 days of 5 min baths, frogs could be cured of Bd infection with fewer side effects and less treatment-associated mortality.

Item ID:	33210
Item Type:	Article (Research - C1)
ISSN:	1940-087X
Related URLs:	http://www.jove.com/video/51166/
Additional Information:	The video component of this article can be found at the link in Related URLs field.
Funders:	Louisiana Deaprtment of Wildlife and Fisheries
Date Deposited:	21 May 2014 05:52
FoR Codes:	07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070706 Veterinary Medicine @ 70% 07 AGRICULTURAL AND VETERINARY SCIENCES > 0702 Animal Production > 070205 Animal Protection (Pests and Pathogens) @ 30%
SEO Codes:	86 MANUFACTURING > 8609 Veterinary Pharmaceutical Products > 860903 Veterinary Pharmaceutical Treatments (e.g. Antibiotics) @ 100%
Downloads:	Total: 2
	More Statistics