Androgen receptor CAG repeat length and TMPRSS2:ETS prostate cancer risk: results from the Prostate Cancer Prevention Trial

Figg, William D., Chau, Cindy H., Price, Douglas K., Till, Cathee, Goodman, Phyllis J., Cho, Yonggon, Varella-Garcia, Marileila, Reichardt, Juergen K.V., Tangen, Catherine M., Leach, Robin J., van Brokhoven, Adrie, Thompson, Ian M., and Lucia, M. Scott (2014) Androgen receptor CAG repeat length and TMPRSS2:ETS prostate cancer risk: results from the Prostate Cancer Prevention Trial. Urology, 84 (1). pp. 127-131.

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Abstract

Objective: To investigate the association between the length of the polymorphic trinucleotide CAG microsatellite repeats in exon 1 of the AR gene and the risk of prostate cancer containing TMPRSS2:ETS fusion genes.

Methods: This nested case-control study came from subjects enrolled in the Prostate Cancer Prevention Trial and included 195 biopsy-proven prostate cancer cases with a known TMPRSS2:ETS status and 1344 matched controls.

Results: There was no association between the CAG repeat length and the risk of TMPRSS2:ETS–positive (odds ratio, 0.97; 95% confidence interval, 0.91-1.04) or TMPRSS2:ETS–negative prostate cancer (odds ratio, 1.04; 95% confidence interval, 0.97-1.11) and in patients with low- or high-grade disease.

Conclusion: Our findings suggested that AR CAG repeats are not associated with TMPRSS2:ETS formation in prostate cancer.

Item ID: 33202
Item Type: Article (Research - C1)
ISSN: 1527-9995
Funders: National Cancer Institute (NCI), The Biology of the Prostrate Cancer Prevention Trial, The University of Colorado Cancer Center, Cancer Therapy and Research Center
Projects and Grants: NCI ZOI BC010453, The Biology of the Prostrate Cancer Prevention Trial P01 CA108964, The University of Colorado Cancer Center Support Grant P30 CA046934, Cancer Therapy and Research Center Support Grant P30 CA054174, NCI Public Health Service Grant CA37429
Date Deposited: 24 Jun 2014 03:08
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111209 Solid Tumours @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111203 Cancer Genetics @ 50%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 100%
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