Plasma angiopoietin-1 is lower after ischemic stroke and associated with major disability but not stroke incidence

Golledge, Jonathan, Clancy, Paula, Maguire, Jane, Lincz, Lisa, Koblar, Simon, McEvoy, Mark, Attia, John, Levi, Chris, Sturm, Jonathan, Almeida, Osvaldo P., Yeap, Bu B., Flicker, Leon, Norman, Paul E., and Hankey, Graeme J. (2014) Plasma angiopoietin-1 is lower after ischemic stroke and associated with major disability but not stroke incidence. Stroke, 45 (4). pp. 1064-1068.

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Abstract

Background and Purpose: Studies in rodent models suggest that upregulating angiopoietin-1 (Angpt1) improves stroke outcomes. The aims of this study were to assess the association of plasma Angpt1 with stroke occurrence and outcome.

Methods: Plasma Angpt1 was measured in 336 patients who had experienced a recent stroke and 321 healthy controls with no stroke history. Patients with stroke (n=285) were reassessed at 3 months and plasma Angpt1 concentration on admission compared between those with severe and minor disability as assessed by the modified Rankin scale. In a separate cohort of 4032 community-acquired older men prospectively followed for a minimum of 6 years, the association of plasma Angpt1 with stroke incidence was examined.

Results: Median plasma Angpt1 was 3-fold lower in patients who had experienced a recent stroke (6.42, interquartile range, 4.26–9.53 compared with 17.36; interquartile range, 14.01–22.46 ng/mL; P<0.001) and remained associated with stroke after adjustment for other risk factors. Plasma Angpt1 concentrations on admission were lower in patients who had severe disability or died at 3 months (median, 5.52; interquartile range, 3.81–8.75 ng/mL for modified Rankin scale 3–6; n=91) compared with those with minor disability (median, 7.04; interquartile range, 4.75–9.92 ng/mL for modified Rankin scale 0–2; n=194), P=0.012, and remained negatively associated with severe disability or death after adjusting for other risk factors. Plasma Angpt1 was not predictive of stroke incidence in community-dwelling older men.

Conclusions: Plasma Angpt1 concentrations are low after ischemic stroke particularly in patients with poor stroke outcomes at 3 months. Interventions effective at upregulating Angpt1 could potentially improve stroke outcomes.

Item ID: 33183
Item Type: Article (Research - C1)
ISSN: 1524-4628
Keywords: angiopoietin-1, biological markers
Funders: Queensland Government, Townsville Hospital Private Practice Fund, National Health and Medical Research Council (NHMRC)
Date Deposited: 14 May 2014 09:55
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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