Neuroendocrine carcinoma of the liver and gallbladder in a cow

Johnson, L. K., Nunez, A., Bracegirdle, J. R., Dwyer, J. R., and Konold, T. (2008) Neuroendocrine carcinoma of the liver and gallbladder in a cow. Journal of Comparative Pathology, 138 (2-3). pp. 165-168.

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A 15-year-old Limousin-cross cow was presented for examination with neurological signs and serum biochemical changes consistent with liver disease. Necropsy revealed enlargement of the liver with multifocal firm, depressed, pale, circumscribed lesions throughout the parenchyma. Within the gallbladder there were exophytic and villiform mucosal masses. Microscopically, hepatic structure was displaced by neoplastic cells forming trabeculac, nests and rosettes. There was transmural infiltration of the gallbladder by similar cells. The histological pattern of growth of the neoplastic cells, the presence of silver-stained cytoplasmic granules within these cells and the immunohistochemical demonstration of chromogranin A supported the diagnosis of neuroendocrine carcinoma. Bovine liver and gallbladder neuroendocrine carcinomas are rare and this is the first detailed documentation of the disease in the United Kingdom.

Item ID: 33167
Item Type: Article (Research - C1)
ISSN: 1532-3129
Keywords: bovine, gallbladder, liver, neuroendocrine carcinoma
Funders: Department for Environment, Food and Rural Affairs TSE Archive (UK)
Projects and Grants: TSE Archive 5700
Date Deposited: 14 May 2014 09:56
FoR Codes: 07 AGRICULTURAL AND VETERINARY SCIENCES > 0707 Veterinary Sciences > 070709 Veterinary Pathology @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1112 Oncology and Carcinogenesis > 111209 Solid Tumours @ 50%
SEO Codes: 83 ANIMAL PRODUCTION AND ANIMAL PRIMARY PRODUCTS > 8303 Livestock Raising > 830301 Beef Cattle @ 100%
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