Enhanced gametocyte formation in erythrocyte progenitor cells: a site-specific adaptation by Plasmodium falciparum

Peatey, Christopher L., Watson, Jolanta A., Trenholme, Katharine R., Brown, Christopher L., Nielson, Lars, Guenther, Marko, Timmins, Nicholas, Watson, Gregory S., and Gardiner, Donald L. (2013) Enhanced gametocyte formation in erythrocyte progenitor cells: a site-specific adaptation by Plasmodium falciparum. Journal of Infectious Diseases, 208 (7). pp. 1170-1174.

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DOI: 10.1093/infdis/jit309

View at Publisher Website: http://dx.doi.org/10.1093/infdis/jit309

Abstract

Gametocytogenesis by Plasmodium falciparum is essential for transmission of the parasite from human to mosquito, yet developing gametocytes lack expression of surface proteins required for cytoadherence. Therefore, elimination from the circulation should occur unless they are sequestered in regions of low blood flow such as the extracellular spaces of the bone marrow. Our data indicate that gametocytogenesis is enhanced in the presence of erythroid progenitors found within the bone marrow. Furthermore, atomic force microscopy indicates that developing gametocytes undergo remarkable shifts in their erythrocyte membrane elasticity, which may allow them to be retained within the bone marrow until maturation.


Item ID:	33096
Item Type:	Article (Research - C1)
ISSN:	1537-6613
Funders:	Griffith University/James Cook University Collaborative Grant
Date Deposited:	12 May 2014 02:55
FoR Codes:	11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110309 Infectious Diseases @ 80% 02 PHYSICAL SCIENCES > 0299 Other Physical Sciences > 029901 Biological Physics @ 20%
SEO Codes:	97 EXPANDING KNOWLEDGE > 970102 Expanding Knowledge in the Physical Sciences @ 20% 97 EXPANDING KNOWLEDGE > 970111 Expanding Knowledge in the Medical and Health Sciences @ 80%
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