CCR6 is transiently upregulated on B cells after activation and modulates the germinal center reaction in the mouse

Wiede, Florian, Fromm, Phillip D., Comerford, Iain, Kara, Ervin, Bannan, Jennifer, Schuh, Wolfgang, Ranasinghe, Charani, Tarlinton, David, Winkler, Thomas, McColl, Shaun R., Körner, Heinrich, and UNSPECIFIED (2013) CCR6 is transiently upregulated on B cells after activation and modulates the germinal center reaction in the mouse. Immunology and Cell Biology, 91 (5). pp. 335-339.

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Abstract

The CC-chemokine receptor 6 (CCR6) is expressed constitutively at an intermediate level on naïve B cells and is upregulated after activation on pregerminal center (GC) B cells. We hypothesized that it could be involved in the events leading to GC reaction and high-affinity antibody production, and therefore investigated the potential role of CCR6 in B-cell differentiation in vivo. After antigenic challenge of CCR6−/− mice with the T-cell-dependent antigen nitrophenyl-keyhole limpet hemocyanin (NP-KLH), GC B-cell development was found to be accelerated and the number of GC had increased significantly compared with control mice, but the antibodies produced by CCR6−/− B cells were on average of lower affinity. We conclude from these data that the CCR6/CCL20 axis has an important role in regulating the kinetics and efficiency of the GC reaction.

Item ID: 33020
Item Type: Article (Research - C1)
ISSN: 1440-1711
Keywords: B cells, germinal centers, chemokine receptor
Funders: NHMRC
Projects and Grants: NHMRC (APP1004592, APP1009002)
Date Deposited: 30 Apr 2014 09:42
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110799 Immunology not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 100%
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