Thrombus volume is similar in patients with ruptured and intact abdominal aortic aneurysms

Golledge, Jonathan, Iyer, Vikram, Jenkins, Julie, Bradshaw, Barbara, Cronin, Oliver, and Walker, Philip J. (2014) Thrombus volume is similar in patients with ruptured and intact abdominal aortic aneurysms. Journal of Vascular Surgery, 59 (2). pp. 315-320.

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Abstract

Objective: Most abdominal aortic aneurysms (AAAs) contain intraluminal thrombus (ILT), which has been demonstrated to contain proteolytic enzymes and proinflammatory cytokines implicated in AAA progression and rupture. In animal models, anticoagulants have been shown to limit AAA progression. Whether ILT plays a role in AAA rupture is unknown.

The aim of this study was to compare the volume of ILT in patients with ruptured and intact AAAs.

Methods: We matched by maximum axial diameter alone, on a 1:2 basis, 28 patients with ruptured AAAs and 56 patients with intact AAAs. Total infrarenal aortic volume and ILT volume were measured from computed tomography angiograms using a previously validated and reproducible semiautomated workstation protocol. Clinical risk factors were also recorded. The Mann-Whitney U test was used to compare ILT volumes between patients with ruptured and intact AAAs.

Results: Median (interquartile range [IQR]) maximum AAA diameter (84.0 [77.5-93.9] mm vs 82.6 [77.1-93.3] mm; P = .769) and median (IQR) total AAA volume (372.8 [277.4-486.1] cm3 vs 358.4 [289.1-563.4] cm3; P = .977) were similar in patients with ruptured and intact AAAs. Median (IQR) AAA ILT volume was similar in patients with ruptured (152.7 [84.8-252.4] cm3) and intact (180.1 [89.9-254.8] cm3; P = .414) AAAs.

Conclusions: This study suggests that ILT volume is not different in ruptured and intact AAAs.

Item ID: 33009
Item Type: Article (Research - C1)
ISSN: 1097-6809
Funders: National Health and Medical Research Council (NHMRC), Queensland Government
Date Deposited: 30 Apr 2014 09:59
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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