Phytochemical and biological activity studies of the Bhutanese medicinal plant corydalis crispa

Wangchuk, Phurpa, Keller, Paul A., Pyne, Stephen G., Sastraruji, Thanapat, Taweechotipatr, Malai, Rattanajak, Roonglawan, Tonsomboon, Aunchalee, and Kamchonwongpaisan, Sumalee (2012) Phytochemical and biological activity studies of the Bhutanese medicinal plant corydalis crispa. Natural Product Communications, 7 (5). pp. 575-580.

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Abstract

The chemical constituents and biological activities of Corydalis crispa (Fumariaceae) were investigated for the first time. The phytochemical study resulted in the isolation of nine known isoquinoline alkaloids: protopine (1), 13-oxoprotopine (2), 13-oxocryptopine (3), stylopine (4), coreximine (5), rheagenine (6), ochrobirine (7), sibiricine (8) and bicuculline (9), with complete NMR data for 2 and 3 provided here for the first time. Crude extracts exhibited significant anti-inflammatory (p<0.01) activity against TNF-α production in LPS activated THP-1 cells. The acetylcholinesterase inhibitory activity of compounds 2, 4 and 7 and the antiplasmodial activity of compound 5 against P. falciparum strains TM4/8.2 and K1CB1 (multidrug resistant strain) are reported here for the first time. Stylopine (4) did not show antimalarial activity against the K1CB1 strain in contrast to a previous report. This study generated a scientific basis for the use of this plant in Bhutanese traditional medicine, either individually or in combination with other medicinal ingredients to treat a broad range of disorders. This study also identified compound 5 as potential new antimalarial lead compound.

Item ID: 32793
Item Type: Article (Research - C1)
ISSN: 1555-9475
Keywords: Corydalis crispa, Isoquinoline alkaloid, Bhutanese traditional medicine, anti-inflammatory, antiplasmodial, anti-acetylcholinesterase
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Funders: Australian Government
Date Deposited: 26 Jun 2014 04:57
FoR Codes: 03 CHEMICAL SCIENCES > 0304 Medicinal and Biomolecular Chemistry > 030401 Biologically Active Molecules @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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