Antiplasmodial agents from the Bhutanese medicinal plant Corydalis calliantha

Wangchuk, Phurpa, Bremner, John B., Samten, , Rattanajak, Roonglawan, and Kamchonwongpaisan, Sumalee (2010) Antiplasmodial agents from the Bhutanese medicinal plant Corydalis calliantha. Phytotherapy Research, 24 (4). pp. 481-485.

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Abstract

The alkaloidal components of the Bhutanese medicinal plant Corydalis calliantha Long, which is used for the treatment of malaria, have been assessed. Four known alkaloids, protopine (1), scoulerine (2), cheilanthifoline (3) and stylopine (4) are reported from this plant for the first time. The protopine alkaloid, protopine, and the tetrahydroprotoberine alkaloid, cheilanthifoline, showed promising in vitro antiplasmodial activities against Plasmodium falciparum, both wild type (TM4) and multidrug resistant (K1) strains with IC50 values in the range of 2.78–4.29 µm. Such activity had not been demonstrated previously for cheilanthifoline. The results thus support, at a molecular level, the clinical use of this plant in the Bhutanese traditional medicine and identified cheilanthifoline as a potential new antimalarial drug lead.

Item ID: 32792
Item Type: Article (Research - C1)
ISSN: 1099-1573
Keywords: antiplasmodial; alkaloids; Corydalis calliantha; medicinal plants; Bhutanese traditional medicine
Funders: Ministry of Health of Buthan, DANIDA project
Date Deposited: 04 Jul 2014 03:01
FoR Codes: 03 CHEMICAL SCIENCES > 0304 Medicinal and Biomolecular Chemistry > 030401 Biologically Active Molecules @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920109 Infectious Diseases @ 100%
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