Community-wide distribution of long-lasting insecticidal nets can halt transmission of lymphatic filariasis in southeastern Nigeria

Richards, Frank O., Emukah, Emmanuel, Graves, Patricia M., Nkwocha, Omeni, Nwankwo, Lawrence, Rakers, Lindsay, Mosher, Aryc, Patterson, Amy, Ozaki, Masayo, Nwoke, Bertram E.B., Ukaga, Chinyere N., Njoku, Chidibere, Nowdu, Kendrick, Obasi, Andrew, and Miri, Emmanuel S. (2013) Community-wide distribution of long-lasting insecticidal nets can halt transmission of lymphatic filariasis in southeastern Nigeria. American Journal of Tropical Medicine and Hygiene, 89 (3). pp. 578-587.

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View at Publisher Website: http://dx.doi.org/10.4269/ajtmh.12-0775
 
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Abstract

Lymphatic filariasis (LF) in rural southeastern Nigeria is transmitted mainly by Anopheles spp. mosquitoes. Potential coinfection with Loa loa in this area has prevented use of ivermectin in the mass drug administration (MDA) strategy for LF elimination because of potential severe adverse L. loa-related reactions. This study determined if long-lasting insecticidal net (LLIN) distribution programs for malaria would interrupt LF transmission in such areas, without need for MDA. Monthly entomologic monitoring was conducted in sentinel villages before and after LLIN distribution to all households and all age groups (full coverage) in two districts, and to pregnant women and children less than five years of age in the other two districts. No change in human LF microfilaremia prevalence was observed, but mosquito studies showed a statistically significant decrease in LF infection and infectivity with full-coverage LLIN distribution. We conclude that LF transmission can be halted in southeastern Nigeria by full-coverage LLIN distribution, without MDA.

Item ID: 32656
Item Type: Article (Research - C1)
ISSN: 1476-1645
Funders: Bill and Melinda Gates Foundation
Date Deposited: 23 Apr 2014 01:31
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111799 Public Health and Health Services not elsewhere classified @ 50%
11 MEDICAL AND HEALTH SCIENCES > 1108 Medical Microbiology > 110803 Medical Parasitology @ 50%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920499 Public Health (excl. Specific Population Health) not elsewhere classified @ 100%
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