Serum osteoprotegerin as a biomarker for vascular disease

Van Campenhout, Ann, Clancy, Paula, and Golledge, Jonathan (2007) Serum osteoprotegerin as a biomarker for vascular disease. American Journal of Cardiology, 100 (3). p. 561.

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We read with great interest the report by Abedin et al1 showing the independent association of plasma osteoprotegerin (OPG) with coronary artery calcium and the presence of aortic plaques in a large, unselected population from the Dallas Heart Study. We congratulate the investigators on their impressive study and support the interest in OPG as a novel biomarker for atherosclerosis.

As stated in their discussion, most previous evidence suggesting an association between circulating OPG and vascular disease focuses on coronary artery disease. To extend these data, our group recently optimized a technique to reproducibly quantify the severity of infrarenal abdominal calcifications using contrast-enhanced computed tomographic angiography (MX800, Philips Medical Systems, Andover, Massachusetts) and appropriate thresholds. Using this technique in patients with peripheral artery disease (n = 109), we found a significant correlation between the severity of infrarenal abdominal aortic calcium and the serum concentration of OPG (r = 0.26, p = 0.006). We also demonstrated marked variation in calculated serum OPG concentrations depending on the enzyme-linked immunosorbent assay used. These variations appear largely attributable to differences in the standards used in the enzyme-linked immunosorbent assays.3 Studies assessing the circulating level of OPG vary in the assay used and the units (picograms per milliliter vs picomoles per liter) in which values are expressed. Average serum OPG concentrations ranging from 3.5 to 18.5 pmol/L have been reported in patients with artery disease. The lack of uniform expression, the different values obtained by different OPG assays, and the different techniques to measure atherosclerosis complicate the assessment of biomarkers. In conclusion, the positive association between OPG and vascular pathology highlights the potential of OPG as a biomarker for vascular disease. To optimize the value of this biomarker, a uniform automated assay expressed in standardized units is required.

Item ID: 32488
Item Type: Article (Commentary)
ISSN: 1879-1913
Date Deposited: 29 Sep 2014 02:21
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1101 Medical Biochemistry and Metabolomics > 110106 Medical Biochemistry: Proteins and Peptides (incl Medical Proteomics) @ 20%
11 MEDICAL AND HEALTH SCIENCES > 1102 Cardiovascular Medicine and Haematology > 110201 Cardiology (incl Cardiovascular Diseases) @ 80%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920103 Cardiovascular System and Diseases @ 100%
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