Global epidemiology of invasive meningococcal disease

Jafri, Rabab Z., Ali, Asad, Messonnier, Nancy E., Tevi-Benissan, Carol, Durrheim, David, Eskola, Juhani, Fermon, Florence, Klugman, Keith P., Ramsay, Mary, Sow, Samba, Zhujun, Shao, Bhutta, Zulfiqar A., and Abramson, Jon (2013) Global epidemiology of invasive meningococcal disease. Population Health Metrics, 11. 17. pp. 1-9.

PDF (Published Version) - Published Version
Available under License Creative Commons Attribution.

Download (448kB) | Preview
View at Publisher Website:


Neisseria meningitidis is one of the leading causes of bacterial meningitis globally and can also cause sepsis, pneumonia, and other manifestations. In countries with high endemic rates, the disease burden places an immense strain on the public health system. The worldwide epidemiology of invasive meningococcal disease (IMD) varies markedly by region and over time. This review summarizes the burden of IMD in different countries and identifies the highest-incidence countries where routine preventive programs against Neisseria meningitidis would be most beneficial in providing protection. Available epidemiological data from the past 20 years in World Health Organization and European Centre for Disease Prevention and Control collections and published articles are included in this review, as well as direct communications with leading experts in the field. Countries were grouped into high-, moderate-, and low-incidence countries. The majority of countries in the high-incidence group are found in the African meningitis belt; many moderate-incidence countries are found in the European and African regions, and Australia, while low-incidence countries include many from Europe and the Americas. Priority countries for vaccine intervention are high- and moderate-incidence countries where vaccine-preventable serogroups predominate. Epidemiological data on burden of IMD are needed in countries where this is not known, particularly in South- East Asia and Eastern Mediterranean regions, so evidence-based decisions about the use of meningococcal vaccines can be made.

Item ID: 32182
Item Type: Article (Research - C1)
ISSN: 1478-7954
Keywords: meningococcus, Neisseria meningitidis, invasive meningococcal disease, meningitis, epidemiology, meningitis belt
Additional Information:

© 2013 Jafri et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Date Deposited: 20 May 2014 06:28
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111799 Public Health and Health Services not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920499 Public Health (excl. Specific Population Health) not elsewhere classified @ 100%
Downloads: Total: 720
Last 12 Months: 83
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page