Predictors and moderators of outcome for severe and enduring anorexia nervosa

Le Grange, Daniel, Fitzsimmons-Craft, Ellen E., Crosby, Ross D., Hay, Phillipa, Lacey, Hubert, Bamford, Bryony, Stiles-Shields, Colleen, and Touyz, Stephen (2014) Predictors and moderators of outcome for severe and enduring anorexia nervosa. Behaviour Research and Therapy, 56. pp. 91-98.

[img] PDF (Published Version) - Published Version
Restricted to Repository staff only

View at Publisher Website:


Few of the limited randomized controlled trials (RCTs) for adults with anorexia nervosa (AN) have explored predictors and moderators of outcome. This study aimed to identify predictors and moderators of outcome at end of treatment (EOT) and 6- and 12-month follow-up for adults with AN (N = 63). All participants met criteria for severe and enduring AN (duration of illness ≥ 7 years) and participated in an RCT of cognitive-behavioral therapy (CBT-AN) and specialist supportive clinical management (SSCM). General linear models were utilized and included all available outcome data at all time points. Outcome was assessed across three domains: eating disorder quality of life (EDQOL), mental health (MCS), and depressive symptoms (BDI). Predictors of better outcome included: lower age, shorter duration of illness, having AN-R, being employed, not taking psychotropic medication, and better social adjustment. Four moderators of treatment outcome emerged: eating disorder psychopathology (EDE Global), depression (BDI), age, and AN subtype. Participants with higher baseline scores on these measures, older age, or binge eating/purging subtype benefited more from CBT-AN than SSCM. Older patients with more severe eating-related psychopathology and depression have better outcomes in a behaviorally targeted treatment such as CBT-AN rather than a supportive treatment such as SSCM.

Item ID: 32160
Item Type: Article (Research - C1)
ISSN: 1873-622X
Keywords: predictors; moderators; severe and enduring anorexia nervosa; CBT-AN; SSCM
Funders: National Health and Medical Research Council of Australia (NHMRC), South-West London and St. George's NHS Trust, Butterfly Foundation, University of Western Sydney
Projects and Grants: NHMRC PG 457419
Date Deposited: 27 May 2015 01:52
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110319 Psychiatry (incl Psychotherapy) @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920199 Clinical Health (Organs, Diseases and Abnormal Conditions) not elsewhere classified @ 100%
Downloads: Total: 8
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page