Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the International Encephalitis Consortium

Venkatesan, A., Tunkel, A.R., Bloch, K.C., Lauring, A.S., Sejvar, J., Bitnun, A., Stahl, J-P., Mailles, A., Drebot, M., Rupprecht, C.E., Yoder, J., Cope, J.R., Wilson, M.R., Whitley, R.J., Sullivan, J., Granerod, J., Jones, C., Eastwood, K., Ward, K.N., Durrheim, D.N., Solbrig, M.V., Guo-Dong, L., and Glaser, C.A. (2013) Case definitions, diagnostic algorithms, and priorities in encephalitis: consensus statement of the International Encephalitis Consortium. Clinical Infectious Diseases, 57 (8). pp. 1114-1128.

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Abstract

Background. Encephalitis continues to result in substantial morbidity and mortality worldwide. Advances in diagnosis and management have been limited, in part, by a lack of consensus on case definitions, standardized diagnostic approaches, and priorities for research.

Methods. In March 2012, the International Encephalitis Consortium, a committee begun in 2010 with members worldwide, held a meeting in Atlanta to discuss recent advances in encephalitis and to set priorities for future study.

Results. We present a consensus document that proposes a standardized case definition and diagnostic guidelines for evaluation of adults and children with suspected encephalitis. In addition, areas of research priority, including host genetics and selected emerging infections, are discussed.

Conclusions. We anticipate that this document, representing a synthesis of our discussions and supported by literature, will serve as a practical aid to clinicians evaluating patients with suspected encephalitis and will identify key areas and approaches to advance our knowledge of encephalitis.

Item ID: 32113
Item Type: Article (Research - C1)
ISSN: 1537-6591
Keywords: encephalitis; guidelines; viral; autoimmune; host genetics
Funders: Centers for Disease Control and Prevention, French Institute for Public Health Surveillance, French Infectious Diseases Society, National Natural Science Foundation of China, Hunter Medical Research Institute , National Institutes of Health (NIH), Manitoba Health Research Council, Public Health England
Projects and Grants: Centers for Disease Control and Prevention U50/CCU915548-03, Centers for Disease Control and Prevention U50/CCU416123, NIH K08 AI081754
Date Deposited: 24 May 2014 05:14
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1117 Public Health and Health Services > 111799 Public Health and Health Services not elsewhere classified @ 100%
SEO Codes: 92 HEALTH > 9204 Public Health (excl. Specific Population Health) > 920499 Public Health (excl. Specific Population Health) not elsewhere classified @ 100%
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