Comparing survival and recurrence in curative stage I to stage III colorectal cancer in transfused and nontransfused patients

Talukder, Yumna, Stillwell, Andrew P., Siu, Simon K., and Ho, Yik-Hong (2014) Comparing survival and recurrence in curative stage I to stage III colorectal cancer in transfused and nontransfused patients. International Surgery, 99 (1). pp. 8-16.

[img]
Preview
PDF (Published Version) - Published Version
Available under License Creative Commons Attribution Non-commercial.

Download (272kB) | Preview
View at Publisher Website: http://dx.doi.org/10.9738/INTSURG-D-13-0...
 
9
159


Abstract

Evidence of the association between blood transfusions and its impact on prognostic outcomes in patients who undergo curative resection of colorectal cancer remains controversial. The aim of this study was to determine whether receiving peri-operative blood transfusions during curative colorectal cancer resection affected overall survival, cancer-related survival, and cancer recurrence. This retrospective study was undertaken at The Royal Brisbane and Women's Hospital, Australia, between 1984 and 2004. The outcomes of 1370 patients undergoing curative colorectal cancer resection for TNM stage I to III were analyzed. Four hundred twenty three patients (30.9%) required transfusion and 947 patients (69.1%) did not. Peri-operative transfusion was associated with higher rates of cancer recurrence on multivariate analysis (P = 0.024, RR, 1.257, 95% CI, 1.03-1.53); however, it was not independently associated with poorer overall or cancer-related survival. Where the aim is curative resection, this study contributes to a body of evidence that blood transfusions may be associated with poorer outcomes.

Item ID: 31967
Item Type: Article (Research - C1)
ISSN: 0020-8868
Keywords: colorectal cancer, overall, cancer-related, disease-free survival, recurrence, transfusion
Additional Information:

© 2014 Talukder et al.; licensee The International College of Surgeons. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-commercial License which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non-commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/3.0

Date Deposited: 23 Jul 2014 00:25
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1103 Clinical Sciences > 110323 Surgery @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920102 Cancer and Related Disorders @ 50%
92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920118 Surgical Methods and Procedures @ 50%
Downloads: Total: 159
Last 12 Months: 14
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page