Bismuth(III) beta-thioxoketonates as antibiotics against Helicobacter pylori and as anti-leishmanial agents

Andrews, Philip C., Blair, Victoria L., Ferrero, Richard L., Junk, Peter C., Kedzierski, Lukasz, and Peiris, Roshani M. (2014) Bismuth(III) beta-thioxoketonates as antibiotics against Helicobacter pylori and as anti-leishmanial agents. Dalton Transactions, 43 (3). pp. 1279-1291.

[img] PDF (Published Version) - Published Version
Restricted to Repository staff only

View at Publisher Website: http://dx.doi.org/10.1039/c3dt52544a
 
18
4


Abstract

Nine different β-thioxoketones of general formula R1C([double bond, length as m-dash]O)CH2C([double bond, length as m-dash]S)R2 (R1 = C6H5, R2 = C6H5L1; R1 = C6H5, R2 = p-CF3C6H4L2; R1 = p-MeOC6H4, R2 = C6H5L3; R1 = p-MeOC6H4, R2 = p-CF3C6H4L4; R1 = C5H4N, R2 = C6H5L5; R1 = p-IC6H4, R2 = C6H5L6; R1 = C6H5, R2 = p-IC6H4L7; R1 = C6H5, R2 = C10H7L8 and R1 = CH3, R2 = C6H5L9) and their tris-substituted bismuth(III) complexes having the general formula [Bi{R1C([double bond, length as m-dash]O)CHC([double bond, length as m-dash]S)R2}3] were synthesised and fully characterised. The solid state structure of [Bi{C5H4NC([double bond, length as m-dash]O)CHC([double bond, length as m-dash]S)C6H5}3] B5 was determined by crystallography and revealed that the three β-thioxoketonato ligands are bound to bismuth(III) centre in a bidentate fashion through O and S atoms. The bismuth(III) complexes and the corresponding thioxoketones were assessed for their activity against H. pylori. All of the bismuth(III) complexes were highly active against H. pylori having a MIC of greater than or equal to 3.125 µg mL−1, while the free acids were essentially not toxic to the bacteria. The anti-leishmanial activity of all the bismuth(III) β-thioxoketonates and the corresponding free acids were assessed against L. major promastigotes. The toxicity towards human fibroblast cells was also assessed. All of the free β-thioxoketones were selectively toxic to the L. major promastigotes displaying some potential as anti-leishmanial agents. Among these [C6H5C([double bond, length as m-dash]O)CH2C([double bond, length as m-dash]S)C6H5] L1 and [C5H4NC([double bond, length as m-dash]O)CH2C([double bond, length as m-dash]S)C6H5] L5 showed comparable activity to that of Amphotericin B, killing about 80% of the L. major promastigotes at a concentration of 25 µM (6.0 µg mL−1). The bismuth(III) β-thioxoketonate complexes were toxic to both the L. major promastigotes and fibroblast cells at high concentrations, but gave no improvement in anti-leishmanial activity over the free β-thioxoketones.

Item ID: 31744
Item Type: Article (Refereed Research - C1)
ISSN: 1477-9234
Funders: Australian Research Council (ARC), Monash University
Date Deposited: 26 Feb 2014 09:39
FoR Codes: 03 CHEMICAL SCIENCES > 0302 Inorganic Chemistry > 030204 Main Group Metal Chemistry @ 100%
SEO Codes: 97 EXPANDING KNOWLEDGE > 970103 Expanding Knowledge in the Chemical Sciences @ 100%
Downloads: Total: 4
More Statistics

Actions (Repository Staff Only)

Item Control Page Item Control Page