Application of anti-BMP antibodies to immunohistochemical examination of fibrous dysplasia

Kiso, Honoka, Takahashi, Katsu, Kang, Yangsun, Saito, Kazuyuki, Togo, Yumiko, Sakata-Goto, Tomoko, Huang, Boyen, Tsukamoto, Hiroko, Nakashima, Yasuaki, and Bessho, Kazuhisa (2015) Application of anti-BMP antibodies to immunohistochemical examination of fibrous dysplasia. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 27 (1). pp. 106-111.

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Objective: Fibrous dysplasia of bone (FD) is a benign developmental disorder of bone in which normal bone is replaced by fibrous tissue, containing trabeculae of immature woven bone. This disease has been classified into three types: monostotic (MFD), polyostotic (PFD), and McCune–Albright syndrome (MAS). Occurring in multiple adjacent craniofacial bones (craniofacial FD) is considered to be an MFD lesion. Surgical reduction is performed for form revision after having observed the progress until adulthood, but postoperative recurrence cases are not rare, there is a report of malignant progression to osteosarcoma, and the clinical phenotypes are generally various. This study aimed to identify the relationship between clinical futures of FD and expression of bone morphogenetic protein (BMP) subtypes.

Methods: We studied 10 cases (9 MFD cases and 1 McCune–Albright syndrome case) diagnosed with fibrous dysplasia in our hospital, and immunohistochemical examinations of the excised sample from each case with anti-BMP-2, 4, 6, and 7 antibodies were performed.

Results: 5 MFD cases and 1 MAS case underwent reoperation, and the case that had the most number of operations was 9 times in the MFD case. Malignant transformations were not identified. BMP-4, 6, and 7 expressions were positive in all cases, but the expression of BMP-2 was positive only in 6 MFD cases. BMP-2 negative cases tended to undergo reoperation.

Conclusions: The variable expression of BMP-2 demonstrated in the current study was suggested to be a useful indication for clinical activity and convalescence of the lesions.

Item ID: 31447
Item Type: Article (Research - C1)
ISSN: 2212-5558
Keywords: fibrous dysplasia of bone; immunohistochemistry; bone morphogenetic protein; maxillofacial
Date Deposited: 26 Jun 2014 02:10
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1105 Dentistry > 110505 Oral Medicine and Pathology @ 60%
10 TECHNOLOGY > 1004 Medical Biotechnology > 100402 Medical Biotechnology Diagnostics (incl Biosensors) @ 40%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920116 Skeletal System and Disorders (incl. Arthritis) @ 100%
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