NOD.Cd1-/- mice have increased numbers of CD4+CD25+Foxp3+ T regulatory cells in the periphery

Vangaveti, Venkat N., Jose, Roby J., and Baxter, Alan G. (2007) NOD.Cd1-/- mice have increased numbers of CD4+CD25+Foxp3+ T regulatory cells in the periphery. In: [Presented at the 8th Annual Retreat of the Brisbane Immunology Group]. From: BIG 2007: 8th Annual Retreat of the Brisbane Immunology Group, 23-24 August 2007, Sunshine Coast, QLD, Australia.

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Abstract

Recent studies indicate Natural Killer T (NKT) lymphocytes and Regulatory T (Treg) cells interact to regulate immune responses. NOD mice bearing a targeted deletion of the NKT cell restriction molecule, CD1d, lack NKT cells. To determine whether absence of NKT cells has an effect on Treg numbers, NOD/Lt and NOD.Cd1-/- mice were examined for differences in their Treg population. Flow cytometric analysis of 10-week old female mice of both strains revealed that NOD.Cd1-/- mice have a higher number of CD4+CD25+Foxp3+ T cells in both the spleen and liver. Further studies on differences in regulatory T cells between these strains at different ages and the effect of adoptive transfer of NKT cells on Treg cells would give us a better understanding about interactions of these two populations.

Item ID: 31411
Item Type: Conference Item (Abstract / Summary)
Keywords: NOD, regulatory cells, NKT cells
Date Deposited: 05 Sep 2017 02:38
FoR Codes: 11 MEDICAL AND HEALTH SCIENCES > 1107 Immunology > 110703 Autoimmunity @ 100%
SEO Codes: 92 HEALTH > 9201 Clinical Health (Organs, Diseases and Abnormal Conditions) > 920104 Diabetes @ 100%
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